Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1451 PA0417 chemotactic transduction protein ChpE chpE, PA0417 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015171Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.847 No Hit N/A —
1452 PA5430 hypothetical protein PA5430 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.846 No Hit N/A —
1453 PA3523 resistance-nodulation-cell division (RND) efflux membrane fusion protein PA3523 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +25 total
0.846 No Hit N/A —
1454 PA2370 hypothetical protein PA2370 AlphaFold – – 0.846 No Hit N/A —
1455 PA1589 succinyl-CoA ligase subunit alpha sucD, PA1589 AlphaFold
6.2.1.5
GO:0042709A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP. GO:0009361A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP. GO:0004550Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. +69 total
0.846 Hit 68.7% 2.31e-63
1456 PA1018 hypothetical protein PA1018 AlphaFold –
GO:0003857Catalysis of the reaction: a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + NADH + H+. GO:0044594Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+. GO:0004300Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O. +14 total
0.846 Hit 34.6% 2.51e-45
1457 PA0655 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase coq7, PA0655 AlphaFold
1.14.99.60
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008682Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + donor-H2 + O2 = acceptor + a 3-demethylubiquinol + H2O. +36 total
0.846 Hit 29.1% 2.34e-06
1458 PA0620 bacteriophage protein PA0620, HR2 Experimental + AlphaFold –
GO:0046872Binding to a metal ion.
0.846 No Hit N/A —
1459 PA0383 hypothetical protein PA0383 AlphaFold – – 0.846 No Hit N/A —
1460 PA0120 transcriptional regulator PA0120 AlphaFold –
GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.846 No Hit N/A —
1461 PA5492 ribosome biogenesis GTP-binding protein YsxC engB, PA5492 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005525Binding to GTP, guanosine triphosphate. GO:0046872Binding to a metal ion. +14 total
0.845 Hit 31.6% 1.48e-18
1462 PA5384 lipolytic protein PA5384 AlphaFold –
GO:0047619Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine. GO:0034338Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.845 Hit 39.3% 7.00e-07
1463 PA5043 type 4 fimbrial biogenesis protein PilN PA5043, pilN Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044096A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. GO:0043683The assembly from its constituent parts of a type IV pilus. +14 total
0.845 No Hit N/A —
1464 PA4970 hypothetical protein PA4970 AlphaFold – – 0.845 No Hit N/A —
1465 PA4437 hypothetical protein PA4437 AlphaFold – – 0.845 No Hit N/A —
1466 PA2836 secretion protein PA2836 AlphaFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.845 No Hit N/A —
1467 PA2129 chaperone CupA2 PA2129, cupA2 AlphaFold –
GO:0097311A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0044183Binding to a protein or a protein-containing complex to assist the protein folding process. +58 total
0.845 No Hit N/A —
1468 PA1817 hypothetical protein PA1817 AlphaFold – – 0.845 No Hit N/A —
1469 PA1539 hypothetical protein PA1539 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.845 No Hit N/A —
1470 PA0945 phosphoribosylformylglycinamidine cyclo-ligase purM, PA0945 AlphaFold
6.3.3.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004637Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate. +47 total
0.845 Hit 50.1% 8.12e-109
1471 PA0451 hypothetical protein PA0451 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.845 No Hit N/A —
1472 PA0072 hypothetical protein PA0072 AlphaFold –
GO:0098797Any protein complex that is part of the plasma membrane. GO:0044874A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.845 No Hit N/A —
1473 PA5138 hypothetical protein PA5138 AlphaFold – – 0.844 No Hit N/A —
1474 PA4621 oxidoreductase PA4621 AlphaFold –
GO:0005506Binding to an iron (Fe) ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.844 Hit 23.6% 1.32e-13
1475 PA4358 ferrous iron transporter B PA4358 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015093Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. GO:0005525Binding to GTP, guanosine triphosphate. +58 total
0.844 No Hit N/A —
Page of 223 · 5572 total proteins