Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1526 PA3163 cytidylate kinase PA3163, cmk AlphaFold
2.7.4.25
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0036430Catalysis of the reaction: ATP + CMP = ADP + CDP. +58 total
0.84 No Hit N/A —
1527 PA1806 NADH-dependent enoyl-ACP reductase fabI, PA1806 Experimental + AlphaFold
1.3.1.9
GO:0004318Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH. GO:0042802Binding to an identical protein or proteins. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units. +14 total
0.84 Hit 34.0% 1.15e-07
1528 PA1556 cbb3-type cytochrome C oxidase subunit II ccoO2, PA1556 AlphaFold –
GO:0004129Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872Binding to a metal ion. +14 total
0.84 No Hit N/A —
1529 PA1325 hypothetical protein PA1325 AlphaFold – – 0.84 No Hit N/A —
1530 PA0644 hypothetical protein PA0644 AlphaFold – – 0.84 No Hit N/A —
1531 PA0275 transcriptional regulator PA0275 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.84 No Hit N/A —
1532 PA0096 hypothetical protein PA0096 AlphaFold – – 0.84 No Hit N/A —
1533 PA4901 benzoylformate decarboxylase PA4901, mdlC AlphaFold
4.1.1.7
GO:0003984Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. GO:0050695Catalysis of the reaction: benzoylformate = benzaldehyde + CO2. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +47 total
0.839 Hit 27.0% 7.50e-06
1534 PA4599 resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC mexC, PA4599 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +25 total
0.839 No Hit N/A —
1535 PA3695 hypothetical protein PA3695 AlphaFold –
GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.839 Hit 29.2% 4.81e-08
1536 PA3453 hypothetical protein PA3453 AlphaFold – – 0.839 No Hit N/A —
1537 PA3263 recombination associated protein RdgC PA3263, rdgC Experimental + AlphaFold –
GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003690Binding to double-stranded DNA. +25 total
0.839 No Hit N/A —
1538 PA2954 hypothetical protein PA2954 AlphaFold – – 0.839 No Hit N/A —
1539 PA2101 hypothetical protein PA2101 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.839 No Hit N/A —
1540 PA2090 hypothetical protein PA2090 AlphaFold –
GO:0008726Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN. GO:0046306The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
0.839 No Hit N/A —
1541 PA2073 transporter membrane subunit PA2073 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.839 No Hit N/A —
1542 PA2071 elongation factor G fusB, PA2071, fusA2 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +47 total
0.839 Hit 56.9% 7.99e-12
1543 PA1884 transcriptional regulator PA1884 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.839 No Hit N/A —
1544 PA5564 16S rRNA methyltransferase GidB gidB ColabFold –
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside.
0.838 No Hit N/A —
1545 PA5520 hypothetical protein PA5520 AlphaFold –
GO:0005515Binding to a protein.
0.838 No Hit N/A —
1546 PA4602 serine hydroxymethyltransferase PA4602, glyA3 AlphaFold
2.1.2.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004372Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +47 total
0.838 Hit 53.8% 7.38e-12
1547 PA4316 exonuclease I sbcB, PA4316 AlphaFold
3.1.11.1
GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0046872Binding to a metal ion. +47 total
0.838 No Hit N/A —
1548 PA3221 molecular chaperone CsaA csaA, PA3221 AlphaFold –
GO:0000049Binding to a transfer RNA.
0.838 Hit 35.6% 9.74e-12
1549 PA3145 glycosyltransferase WbpL PA3145, wbpL AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0046872Binding to a metal ion. +69 total
0.838 No Hit N/A —
1550 PA3067 transcriptional regulator PA3067 Experimental + AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.838 No Hit N/A —
Page of 223 · 5572 total proteins