Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1476 PA3335 hypothetical protein PA3335 Experimental + AlphaFold – – 0.844 No Hit N/A —
1477 PA3044 two-component sensor PA3044 AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009927Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +47 total
0.844 No Hit N/A —
1478 PA2972 hypothetical protein PA2972 AlphaFold
3.6.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0047429Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. GO:0009117The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
0.844 Hit 29.4% 1.15e-14
1479 PA2579 tryptophan 2,3-dioxygenase kynA, PA2579 AlphaFold
1.13.11.11
GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0004833Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. GO:0046872Binding to a metal ion. +25 total
0.844 Hit 44.2% 2.56e-07
1480 PA2438 hypothetical protein PA2438 AlphaFold –
GO:0098797Any protein complex that is part of the plasma membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0052547Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.
0.844 No Hit N/A —
1481 PA1495 hypothetical protein PA1495 AlphaFold – – 0.844 No Hit N/A —
1482 PA1247 alkaline protease secretion protein AprE aprE, PA1247 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009306The controlled release of proteins from a cell. GO:0046903The controlled release of a substance by a cell or a tissue. +36 total
0.844 No Hit N/A —
1483 PA1079 flagellar basal body rod modification protein PA1079, flgD Experimental + AlphaFold –
GO:0044781A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.
0.844 No Hit N/A —
1484 PA0537 hypothetical protein PA0537 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.844 No Hit N/A —
1485 PA5016 dihydrolipoamide acetyltransferase aceB, aceF, PA5016 AlphaFold
2.3.1.12
GO:0045254A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. GO:0004742Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA. GO:0006086The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH. +25 total
0.843 Hit 34.2% 1.85e-33
1486 PA4794 hypothetical protein PA4794 Experimental + AlphaFold –
GO:0046872Binding to a metal ion. GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.843 No Hit N/A —
1487 PA4635 hypothetical protein PA4635 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.843 No Hit N/A —
1488 PA4503 ABC transporter permease PA4503 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.843 No Hit N/A —
1489 PA4379 hypothetical protein PA4379 AlphaFold –
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
0.843 No Hit N/A —
1490 PA2998 Na(+)-translocating NADH-quinone reductase subunit B nqrB, PA2998 AlphaFold
7.2.1.1
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. +47 total
0.843 No Hit N/A —
1491 PA2493 resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexE mexE, PA2493 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +25 total
0.843 No Hit N/A —
1492 PA2412 hypothetical protein PA2412 Experimental + AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002049The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine. GO:0019290The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
0.843 No Hit N/A —
1493 PA1492 hypothetical protein PA1492 Experimental + AlphaFold – – 0.843 No Hit N/A —
1494 PA0284 hypothetical protein PA0284 AlphaFold – – 0.843 No Hit N/A —
1495 PA0270 hypothetical protein PA0270 AlphaFold – – 0.843 No Hit N/A —
1496 PA5546 hypothetical protein PA5546 AlphaFold –
GO:0008825Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. GO:0008610The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.842 No Hit N/A —
1497 PA5161 dTDP-D-glucose 4,6-dehydratase PA5161, rmlB AlphaFold
4.2.1.46
GO:0008460Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O. GO:0019305The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate. GO:0009244The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. +25 total
0.842 Hit 34.0% 5.32e-62
1498 PA4373 hypothetical protein PA4373 AlphaFold –
GO:0005515Binding to a protein.
0.842 No Hit N/A —
1499 PA4128 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase PA4128 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. GO:0046872Binding to a metal ion. +36 total
0.842 No Hit N/A —
1500 PA3750 hypothetical protein PA3750 AlphaFold –
GO:0004622Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.
0.842 No Hit N/A —
Page of 223 · 5572 total proteins