Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1651 PA4528 type 4 prepilin peptidase PilD PA4528, pilD, xcpA AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. +710 total
0.829 No Hit N/A —
1652 PA4441 hypothetical protein PA4441 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0008360Any process that modulates the surface configuration of a cell.
0.829 No Hit N/A —
1653 PA3968 pseudouridine synthase rluE, PA3968 AlphaFold
5.4.99.20
GO:0160137Catalysis of the reaction: uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. +47 total
0.829 No Hit N/A —
1654 PA3829 hypothetical protein PA3829 AlphaFold –
GO:0052689Catalysis of the hydrolysis of a carboxylic ester bond. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.829 No Hit N/A —
1655 PA2611 siroheme synthase PA2611, cysG AlphaFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0043115Catalysis of the reaction: NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin. GO:0051266Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. +69 total
0.829 No Hit N/A —
1656 PA2346 hypothetical protein PA2346 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003995Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +36 total
0.829 Hit 20.8% 1.05e-07
1657 PA2345 hypothetical protein PA2345 AlphaFold –
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. GO:0070224Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone. +25 total
0.829 Hit 38.6% 4.44e-39
1658 PA2094 transmembrane sensor PA2094 AlphaFold – – 0.829 No Hit N/A —
1659 PA1465 hypothetical protein PA1465 AlphaFold – – 0.829 No Hit N/A —
1660 PA1433 hypothetical protein PA1433 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:1900190Any process that modulates the frequency, rate or extent of single-species biofilm formation. +25 total
0.829 No Hit N/A —
1661 PA0894 hypothetical protein PA0894 AlphaFold – – 0.829 No Hit N/A —
1662 PA0813 hypothetical protein PA0813 AlphaFold –
GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. GO:0006534OBSOLETE. The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.829 Hit 24.2% 1.60e-07
1663 PA5355 glycolate oxidase subunit GlcD glcD, PA5355 AlphaFold –
GO:0009339An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and H2O2. The enzyme is a flavoprotein (FMN). GO:0003973Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + H2O2. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +47 total
0.828 Hit 39.6% 3.13e-12
1664 PA4580 hypothetical protein PA4580 AlphaFold – – 0.828 No Hit N/A —
1665 PA3949 hypothetical protein PA3949 AlphaFold – – 0.828 No Hit N/A —
1666 PA3513 hypothetical protein PA3513 AlphaFold –
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
0.828 No Hit N/A —
1667 PA3502 hypothetical protein PA3502 AlphaFold – – 0.828 No Hit N/A —
1668 PA2281 transcriptional regulator PA2281 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0009893Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. +14 total
0.828 No Hit N/A —
1669 PA1513 hypothetical protein PA1513 AlphaFold – – 0.828 No Hit N/A —
1670 PA0862 hypothetical protein PA0862 AlphaFold – – 0.828 No Hit N/A —
1671 PA0052 hypothetical protein PA0052 AlphaFold – – 0.828 No Hit N/A —
1672 PA4079 short-chain dehydrogenase PA4079 Experimental + AlphaFold –
GO:0004090Catalysis of the reaction: a secondary alcohol + NADP+ = a ketone + H+ + NADPH. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
0.827 No Hit N/A —
1673 PA3219 hypothetical protein PA3219 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872Binding to a metal ion. GO:0008758Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP. +14 total
0.827 No Hit N/A —
1674 PA2296 hypothetical protein PA2296 AlphaFold – – 0.827 No Hit N/A —
1675 PA2184 hypothetical protein PA2184 AlphaFold – – 0.827 No Hit N/A —
Page of 223 · 5572 total proteins