Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1676 PA1712 exoenzyme S synthesis protein ExsB PA1712, exsB Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
0.827 No Hit N/A —
1677 PA1644 hypothetical protein PA1644 AlphaFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016646Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.827 No Hit N/A —
1678 PA1191 hypothetical protein PA1191 AlphaFold – – 0.827 No Hit N/A —
1679 PA5057 poly(3-hydroxyalkanoic acid) depolymerase catD_2, PA5057, phaZ, phaD AlphaFold –
GO:0004806Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+. GO:0046503The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone.
0.826 No Hit N/A —
1680 PA4604 hypothetical protein PA4604 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.826 Hit 45.9% 1.45e-12
1681 PA3538 ABC transporter ATP-binding protein PA3538 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015408Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in). +710 total
0.826 Hit 34.1% 6.99e-06
1682 PA3240 quercetin 2,3-dioxygenase PA3240 AlphaFold
1.13.11.24
GO:0046872Binding to a metal ion. GO:0008127Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO.
0.826 Hit 39.2% 6.89e-56
1683 PA1860 hypothetical protein PA1860 AlphaFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.826 No Hit N/A —
1684 PA1605 hypothetical protein PA1605 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.826 No Hit N/A —
1685 PA1473 hypothetical protein PA1473 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009306The controlled release of proteins from a cell.
0.826 No Hit N/A —
1686 PA1463 hypothetical protein orf4, PA1463 AlphaFold –
GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
0.826 No Hit N/A —
1687 PA1197 NAD-dependent protein deacylase cobB2, PA1197 AlphaFold
2.3.1.286
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. +25 total
0.826 Hit 37.9% 1.75e-21
1688 PA1077 flagellar basal-body rod protein FlgB flgB, PA1077 AlphaFold –
GO:0009288A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0030694The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings. GO:0071978Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. +14 total
0.826 No Hit N/A —
1689 PA0356 hypothetical protein PA0356 AlphaFold – – 0.826 No Hit N/A —
1690 PA0051 phenazine-modifying protein PA0051, phzH AlphaFold
6.3.5.4
GO:0004066Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006529OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.
0.826 Hit 35.9% 9.82e-10
1691 PA5308 leucine-responsive regulatory protein lrp, PA5308 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006524OBSOLETE. The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid. +25 total
0.825 No Hit N/A —
1692 PA4968 hypothetical protein PA4968 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016788Catalysis of the hydrolysis of any ester bond.
0.825 No Hit N/A —
1693 PA4628 lysine-specific permease lysP, PA4628 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015171Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.825 Hit 24.9% 2.60e-11
1694 PA4361 oxidoreductase PA4361 AlphaFold – – 0.825 Hit 31.4% 1.77e-19
1695 PA4116 heme oxygenase BphO bphO, PA4116 AlphaFold –
GO:0004392Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]. GO:0006788The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme.
0.825 No Hit N/A —
1696 PA3443 ABC transporter permease PA3443 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042918The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.825 No Hit N/A —
1697 PA3275 hypothetical protein PA3275 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.825 No Hit N/A —
1698 PA3010 hypothetical protein PA3010 AlphaFold – – 0.825 No Hit N/A —
1699 PA3005 beta-hexosaminidase PA3005, nagZ Experimental + AlphaFold
3.2.1.52
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016231Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +811 total
0.825 No Hit N/A —
1700 PA2533 sodium:alanine symporter PA2533 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005283Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.825 No Hit N/A —
Page of 223 · 5572 total proteins