Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

Search, filter, and prioritize proteins.

Export view
5572 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
151 PA0396 twitching motility protein PilU pilT_1, pilU, PA0396 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +25 total
0.955 No Hit N/A —
152 PA5099 transporter PA5099 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.954 No Hit N/A —
153 PA4924 hypothetical protein PA4924 AlphaFold –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.954 No Hit N/A —
154 PA4828 hypothetical protein PA4828 AlphaFold – – 0.954 No Hit N/A —
155 PA4718 hypothetical protein PA4718 AlphaFold – – 0.954 No Hit N/A —
156 PA1939 hypothetical protein PA1939 AlphaFold – – 0.954 No Hit N/A —
157 PA1377 hypothetical protein PA1377 Experimental + AlphaFold –
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.954 No Hit N/A —
158 PA0938 hypothetical protein PA0938 AlphaFold –
GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0098567The leaflet of the plasma membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it. +58 total
0.954 No Hit N/A —
159 PA0900 hypothetical protein PA0900 AlphaFold – – 0.954 No Hit N/A —
160 PA0204 ABC transporter permease PA0204 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015417Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.954 No Hit N/A —
161 PA5072 chemotaxis transducer mcpK, PA5072 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +25 total
0.953 No Hit N/A —
162 PA3730 hypothetical protein PA3730 AlphaFold – – 0.953 No Hit N/A —
163 PA3517 adenylosuccinate lyase PA3517 AlphaFold
5.5.1.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0070626Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. GO:0047472Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+. +58 total
0.953 Hit 25.6% 1.16e-24
164 PA3403 hypothetical protein PA3403 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016036Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.953 No Hit N/A —
165 PA3395 membrane protein NosY nosY, PA3395 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.953 No Hit N/A —
166 PA3339 patatin-like protein plpD, PA3339 Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016298Catalysis of the hydrolysis of a lipid. +47 total
0.953 Hit 31.9% 2.62e-26
167 PA3315 phosphonates ABC transporter permease PA3315 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.953 No Hit N/A —
168 PA1476 heme exporter protein CcmB ccmB, PA1476 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015232Enables the transfer of heme from one side of a membrane to the other. GO:1903607The chemical reactions and pathways resulting in the formation of cytochrome c. +36 total
0.953 No Hit N/A —
169 PA0304 polyamine transporter PotI PA0304, spuH AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015417Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). GO:0015847The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. +36 total
0.953 No Hit N/A —
170 PA4665 peptide chain release factor 1 prf1, prfA, PA4665 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016149A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. GO:0003747Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. +14 total
0.952 Hit 61.5% 1.78e-47
171 PA4317 hypothetical protein PA4317 AlphaFold – – 0.952 No Hit N/A —
172 PA3702 two-component response regulator PA3702, wspR Experimental + AlphaFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0042802Binding to an identical protein or proteins. +58 total
0.952 No Hit N/A —
173 PA2946 hypothetical protein ColabFold – – 0.952 No Hit N/A —
174 PA2670 hypothetical protein PA2670 AlphaFold – – 0.952 No Hit N/A —
175 PA2478 thiol:disulfide interchange protein DsbD PA2478, dsbD2 AlphaFold
1.8.1.8
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0047134Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. +47 total
0.952 No Hit N/A —
Page of 223 · 5572 total proteins