Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
101 PA3332 hypothetical protein PA3332 Experimental + AlphaFold – – 0.961 No Hit N/A —
102 PA2872 hypothetical protein PA2872 AlphaFold – – 0.961 No Hit N/A —
103 PA1715 type III export apparatus protein PA1715, pscB AlphaFold –
GO:0030254The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
0.961 No Hit N/A —
104 PA0125 hypothetical protein PA0125 Experimental + AlphaFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.961 No Hit N/A —
105 PA0124 hypothetical protein PA0124 Experimental + AlphaFold – – 0.961 No Hit N/A —
106 PA5477 hypothetical protein PA5477 AlphaFold – – 0.96 No Hit N/A —
107 PA5294 multidrug efflux protein NorA norM, PA5294 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0098567The leaflet of the plasma membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +58 total
0.96 Hit 26.4% 3.15e-12
108 PA5022 potassium efflux protein KefA PA5022 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0009992A homeostatic process involved in the maintenance of a steady state level of water within a cell. +25 total
0.96 No Hit N/A —
109 PA4322 hypothetical protein PA4322 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.96 No Hit N/A —
110 PA3781 transporter PA3781 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.96 No Hit N/A —
111 PA3557 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE arnE, PA3557 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1901505Enables the transfer of carbohydrate derivative from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +47 total
0.96 No Hit N/A —
112 PA2135 transporter PA2135 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015386Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). GO:0030007A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. +58 total
0.96 No Hit N/A —
113 PA1981 hypothetical protein PA1981 AlphaFold – – 0.96 Hit 33.0% 4.17e-16
114 PA1650 transporter PA1650 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.96 Hit 31.7% 1.29e-19
115 PA1275 cobalamin biosynthesis protein CobD PA1275, cobD AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015420Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin. GO:0048472Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2. +36 total
0.96 No Hit N/A —
116 PA1193 hypothetical protein PA1193 AlphaFold –
GO:0008725Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
0.96 No Hit N/A —
117 PA5332 catabolite repression control protein exoA, crc, PA5332 Experimental + AlphaFold –
GO:0003906Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). GO:0008311Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. GO:0046872Binding to a metal ion. +811 total
0.959 Hit 32.7% 8.15e-11
118 PA4345 hypothetical protein PA4345 AlphaFold –
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
0.959 No Hit N/A —
119 PA4065 hypothetical protein PA4065 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.959 No Hit N/A —
120 PA3006 transcriptional regulator PsrA PA3006, psrA Experimental + AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +47 total
0.959 No Hit N/A —
121 PA1044 hypothetical protein PA1044 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.959 No Hit N/A —
122 PA1035 hypothetical protein PA1035 AlphaFold –
GO:0009269Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water.
0.959 No Hit N/A —
123 PA0811 major facilitator superfamily transporter PA0811 AlphaFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.959 Hit 24.7% 3.33e-06
124 PA4962 hypothetical protein PA4962 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.958 No Hit N/A —
125 PA4307 chemotactic transducer PctC pctC, PA4307 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +36 total
0.958 No Hit N/A —
Page of 223 · 5572 total proteins