Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
126 PA1157 two-component response regulator PA1157 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +47 total
0.958 No Hit N/A —
127 PA1141 transcriptional regulator PA1141 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.958 No Hit N/A —
128 PA0635 hypothetical protein PA0635 AlphaFold – – 0.958 No Hit N/A —
129 PA5527 hypothetical protein PA5527 AlphaFold – – 0.957 No Hit N/A —
130 PA4535 hypothetical protein PA4535 Experimental + AlphaFold – – 0.957 No Hit N/A —
131 PA3435 flavodoxin PA3435 Experimental + AlphaFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
0.957 Hit 37.6% 5.43e-09
132 PA2340 binding-protein-dependent maltose/mannitol transport protein PA2340 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.957 No Hit N/A —
133 PA0606 ABC transporter permease PA0606 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.957 No Hit N/A —
134 PA0411 twitching motility protein PilJ pilJ, PA0411 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +25 total
0.957 No Hit N/A —
135 PA0309 hypothetical protein PA0309 AlphaFold – – 0.957 No Hit N/A —
136 PA5533 hypothetical protein PA5533 AlphaFold – – 0.956 No Hit N/A —
137 PA5333 hypothetical protein PA5333 AlphaFold – – 0.956 No Hit N/A —
138 PA3438 GTP cyclohydrolase I PA3438, folE1 AlphaFold
3.5.4.16
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003934Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+. +47 total
0.956 Hit 57.8% 8.37e-79
139 PA3003 hypothetical protein PA3003 AlphaFold – – 0.956 No Hit N/A —
140 PA2698 hydrolase PA2698 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.956 No Hit N/A —
141 PA2240 biofilm formation protein PslJ PA2240, pslJ AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. +14 total
0.956 No Hit N/A —
142 PA1485 amino acid permease PA1485 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015179Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. GO:0003333The process in which an amino acid is transported across a membrane. +36 total
0.956 Hit 32.1% 1.76e-06
143 PA1445 flagellar protein FliO fliO, PA1445 AlphaFold –
GO:0009425One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0097588Cell motility due to movement of bacterial- or archaeal-type flagella. +36 total
0.956 No Hit N/A —
144 PA0738 hypothetical protein PA0738 AlphaFold – – 0.956 No Hit N/A —
145 PA0156 resistance-nodulation-cell division (RND) efflux membrane fusion protein PA0156 AlphaFold –
GO:1990281A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.956 No Hit N/A —
146 PA5075 ABC transporter permease PA5075 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +47 total
0.955 No Hit N/A —
147 PA4315 transcriptional regulator MvaT PA4315, mvaT AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +36 total
0.955 No Hit N/A —
148 PA2351 ABC transporter permease PA2351 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0048473The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.955 No Hit N/A —
149 PA1411 hypothetical protein PA1411 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.955 No Hit N/A —
150 PA0543 hypothetical protein PA0543 AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.955 No Hit N/A —
Page of 223 · 5572 total proteins