Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1776 PA4872 hypothetical protein PA4872 Experimental + AlphaFold
4.1.1.112
GO:0000287Binding to a magnesium (Mg) ion. GO:0046421Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. GO:0008948Catalysis of the reaction: H+ + oxaloacetate = CO2 + pyruvate. +47 total
0.818 No Hit N/A —
1777 PA4712 hypothetical protein PA4712 AlphaFold – – 0.818 No Hit N/A —
1778 PA4516 hypothetical protein PA4516 AlphaFold –
GO:0005515Binding to a protein.
0.818 Hit 31.6% 2.17e-06
1779 PA4430 cytochrome b PA4430 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0045275A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. GO:0046872Binding to a metal ion. +47 total
0.818 Hit 44.8% 6.37e-90
1780 PA2923 histidine ABC transporter substrate-binding protein HisJ hisJ, PA2923 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents.
0.818 No Hit N/A —
1781 PA2490 hypothetical protein PA2490 AlphaFold – – 0.818 No Hit N/A —
1782 PA2041 amino acid permease PA2041 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.818 Hit 26.3% 1.22e-12
1783 PA1899 phenazine biosynthesis protein PhzA phzA2, PA1899 AlphaFold –
GO:0002047The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. GO:0017000The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
0.818 No Hit N/A —
1784 PA1625 hypothetical protein PA1625 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.818 No Hit N/A —
1785 PA0577 DNA primase PA0577, dnaG Experimental + AlphaFold
2.7.7.101
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000428A protein complex that possesses DNA-directed RNA polymerase activity. GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. +710 total
0.818 No Hit N/A —
1786 PA5217 iron ABC transporter substrate-binding protein PA5217 AlphaFold – – 0.817 No Hit N/A —
1787 PA4004 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH PA4004, rlmH AlphaFold
2.1.1.177
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0070038Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine. GO:0070475The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. +25 total
0.817 No Hit N/A —
1788 PA3331 cytochrome P450 PA3331 AlphaFold –
GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005506Binding to an iron (Fe) ion. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. +14 total
0.817 Hit 29.1% 9.04e-09
1789 PA1976 sensor histidine kinase ercS', PA1976 AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009927Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +58 total
0.817 No Hit N/A —
1790 PA1847 Fe/S biogenesis protein NfuA PA1847, nfuA AlphaFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005506Binding to an iron (Fe) ion. GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. +25 total
0.817 Hit 35.5% 3.69e-06
1791 PA1367 hypothetical protein PA1367 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
0.817 Hit 27.8% 6.53e-09
1792 PA0951a hypothetical protein ColabFold – – 0.817 No Hit N/A —
1793 PA0762 RNA polymerase sigma factor AlgU algU, PA0762, algT Experimental + AlphaFold –
GO:0000345The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. +1619 total
0.817 No Hit N/A —
1794 PA0547 transcriptional regulator PA0547 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008757Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. +14 total
0.817 No Hit N/A —
1795 PA0254 hypothetical protein hudA, PA0254 Experimental + AlphaFold
4.1.1.93
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008694Catalysis of the reaction: a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + H+ = a 2-(all-trans-polyprenyl)phenol + CO2. +47 total
0.817 No Hit N/A —
1796 PA0152 transcriptional regulator PcaQ PA0152, pcaQ AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.817 No Hit N/A —
1797 PA5399 dimethylglycine catabolism protein DgcB PA5399, dgcB AlphaFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0047865Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein. GO:0047866Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = formaldehyde + H2O2 + sarcosine. +58 total
0.816 No Hit N/A —
1798 PA5234 oxidoreductase PA5234 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.816 Hit 44.9% 1.06e-11
1799 PA4990 SMR multidrug efflux transporter PA4990 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015199Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). +710 total
0.816 No Hit N/A —
1800 PA4087 hypothetical protein PA4087 AlphaFold – – 0.816 No Hit N/A —
Page of 223 · 5572 total proteins