Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1826 PA4942 protease subunit HflK PA4942, hflK AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.814 Hit 26.2% 1.28e-09
1827 PA3569 3-hydroxyisobutyrate dehydrogenase PA3569, mmsB AlphaFold
1.1.1.31
GO:0008442Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +36 total
0.814 Hit 48.2% 2.50e-48
1828 PA3308 RNA polymerase-associated protein RapA hepA, rapA, PA3308 AlphaFold
3.6.4.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003682Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +710 total
0.814 Hit 30.3% 1.45e-06
1829 PA2034 hypothetical protein PA2034 AlphaFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
0.814 No Hit N/A —
1830 PA1960 hypothetical protein PA1960 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003730Binding to a 3' untranslated region of an mRNA molecule. GO:0043488Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. +14 total
0.814 No Hit N/A —
1831 PA1700 hypothetical protein PA1700 AlphaFold –
GO:0030254The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. GO:0009306The controlled release of proteins from a cell.
0.814 No Hit N/A —
1832 PA1334 oxidoreductase PA1334 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016628Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. +14 total
0.814 No Hit N/A —
1833 PA5242 polyphosphate kinase ppk, PA5242 AlphaFold
2.7.4.1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009358A protein complex that possesses polyphosphate kinase activity. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.813 No Hit N/A —
1834 PA5137 hypothetical protein PA5137 AlphaFold – – 0.813 No Hit N/A —
1835 PA3963 transporter PA3963 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015086Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other. GO:0015093Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. +69 total
0.813 No Hit N/A —
1836 PA3848 hypothetical protein PA3848 AlphaFold – – 0.813 No Hit N/A —
1837 PA3693 hypothetical protein PA3693 AlphaFold –
GO:0061463Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate. Removes the acetyl group from either the 2'' or 3'' position of O-acetyl-ADP-ribose.
0.813 Hit 59.1% 2.00e-43
1838 PA2484 hypothetical protein PA2484 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
0.813 No Hit N/A —
1839 PA2223 hypothetical protein PA2223 AlphaFold –
GO:0003796Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. GO:0042742Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. GO:0031640Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
0.813 No Hit N/A —
1840 PA1761 hypothetical protein PA1761 AlphaFold – – 0.813 No Hit N/A —
1841 PA1306 HIT family protein PA1306 AlphaFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009117The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
0.813 Hit 31.0% 1.26e-08
1842 PA0826 hypothetical protein PA0826 AlphaFold – – 0.813 No Hit N/A —
1843 PA0775 tRNA (cmo5U34)-methyltransferase PA0775, cmoA AlphaFold
2.1.3.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016743Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +25 total
0.813 No Hit N/A —
1844 PA0486 serine/threonine protein kinase srkA, PA0486 AlphaFold
2.7.11.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. +36 total
0.813 No Hit N/A —
1845 PA0433 hypothetical protein PA0433 AlphaFold – – 0.813 No Hit N/A —
1846 PA0272 transcriptional regulator PA0272 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.813 No Hit N/A —
1847 PA0200 hypothetical protein PA0200 AlphaFold – – 0.813 No Hit N/A —
1848 PA5258 hypothetical protein PA5258 AlphaFold – – 0.812 No Hit N/A —
1849 PA4714 hypothetical protein PA4714 Experimental + AlphaFold –
GO:0046872Binding to a metal ion.
0.812 No Hit N/A —
1850 PA4687 ferric iron-binding periplasmic protein HitA hitA, PA4687 Experimental + AlphaFold –
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0046872Binding to a metal ion.
0.812 No Hit N/A —
Page of 223 · 5572 total proteins