Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1876 PA5065 ubiquinone biosynthetic protein UbiB ubiB, PA5065 AlphaFold
2.7.-.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004672Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. +25 total
0.81 Hit 33.1% 4.53e-14
1877 PA4993 hypothetical protein PA4993 AlphaFold – – 0.81 No Hit N/A —
1878 PA4606 hypothetical protein PA4606 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0031669Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. GO:0009267Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. +14 total
0.81 No Hit N/A —
1879 PA4266 elongation factor G fusA, fusA1, PA4266 Experimental + AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +47 total
0.81 Hit 61.4% 3.04e-15
1880 PA4224 pyochelin biosynthetic protein PchG pchG, PA4224 AlphaFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.81 No Hit N/A —
1881 PA4078 nonribosomal peptide synthetase PA4078 AlphaFold –
GO:0031177Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).
0.81 Hit 31.0% 2.97e-13
1882 PA3382 phosphonate transporter PhnE PA3382, phnE AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015416Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.81 No Hit N/A —
1883 PA3216 hypothetical protein PA3216 AlphaFold – – 0.81 No Hit N/A —
1884 PA3205 hypothetical protein PA3205 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0051082Binding to an unfolded protein. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.81 No Hit N/A —
1885 PA2562 hypothetical protein PA2562 AlphaFold – – 0.81 No Hit N/A —
1886 PA2396 pyoverdine synthetase F pvdF, PA2396 Experimental + AlphaFold
2.1.2.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033608Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA. +47 total
0.81 No Hit N/A —
1887 PA1538 flavin-containing monooxygenase PA1538 AlphaFold
1.14.13.-
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. GO:0004499Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. +25 total
0.81 Hit 26.4% 3.32e-09
1888 PA1166 hypothetical protein PA1166 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.81 No Hit N/A —
1889 PA0703 major facilitator superfamily transporter PA0703 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.81 No Hit N/A —
1890 PA5179 transcriptional regulator PA5179 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:2000142Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. +14 total
0.809 No Hit N/A —
1891 PA4751 cell division protein FtsH PA4751, ftsH AlphaFold
3.4.24.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +811 total
0.809 Hit 57.5% 2.24e-27
1892 PA3139 aspartate aminotransferase PA3139, aspC AlphaFold
2.6.1.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042802Binding to an identical protein or proteins. GO:0004069Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. +710 total
0.809 Hit 43.4% 7.90e-117
1893 PA3131 aldolase PA3131 AlphaFold
4.1.2.14
GO:0106009Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. Specific for the (4S) enantiomer of 4-hydroxy-2-oxoglutarate. GO:0008675Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. +25 total
0.809 No Hit N/A —
1894 PA2828 aminotransferase PA2828 AlphaFold
2.6.1.2
GO:0004021Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0030632The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid. +36 total
0.809 Hit 37.2% 2.16e-21
1895 PA2631 acetyltransferase PA2631 AlphaFold –
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.809 No Hit N/A —
1896 PA2354 transcriptional regulator PA2354 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +58 total
0.809 No Hit N/A —
1897 PA1994 hypothetical protein PA1994 Experimental + AlphaFold – – 0.809 No Hit N/A —
1898 PA1909 hypothetical protein PA1909 AlphaFold – – 0.809 No Hit N/A —
1899 PA1713 exoenzyme S transcriptional regulator ExsA exsA, PA1713 Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +58 total
0.809 No Hit N/A —
1900 PA1658 hypothetical protein PA1658 AlphaFold –
GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
0.809 No Hit N/A —
Page of 223 · 5572 total proteins