Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1926 PA1896 hypothetical protein PA1896 AlphaFold – – 0.807 No Hit N/A —
1927 PA1050 hypothetical protein PA1050 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
0.807 No Hit N/A —
1928 PA0743 NAD-dependent L-serine dehydrogenase PA0743 Experimental + AlphaFold
1.1.1.387
GO:0008442Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +58 total
0.807 Hit 44.5% 9.38e-45
1929 PA0670 hypothetical protein PA0670 AlphaFold –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
0.807 No Hit N/A —
1930 PA0641 bacteriophage protein PA0641 AlphaFold –
GO:0005515Binding to a protein.
0.807 No Hit N/A —
1931 PA0391 hypothetical protein PA0391 AlphaFold – – 0.807 No Hit N/A —
1932 PA0271 hypothetical protein PA0271 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.807 No Hit N/A —
1933 PA0226 CoA transferase subunit A PA0226 AlphaFold
2.8.3.6
GO:0047569Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA. GO:0042952A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.807 No Hit N/A —
1934 PA5530 MFS dicarboxylate transporter PA5530 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015294Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). GO:0006835The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +58 total
0.806 No Hit N/A —
1935 PA5231 ABC transporter ATP-binding protein/permease PA5231 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
0.806 Hit 37.1% 2.08e-30
1936 PA4523 hypothetical protein PA4523 AlphaFold – – 0.806 No Hit N/A —
1937 PA3820 preprotein translocase subunit SecF secF, PA3820 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015450Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. GO:0065002The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. +47 total
0.806 No Hit N/A —
1938 PA3432 hypothetical protein PA3432 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.806 No Hit N/A —
1939 PA2109 hypothetical protein PA2109 AlphaFold – – 0.806 No Hit N/A —
1940 PA0884 C4-dicarboxylate-binding protein PA0884 Experimental + AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015740The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.806 No Hit N/A —
1941 PA0084 hypothetical protein PA0084, tssC1 AlphaFold – – 0.806 No Hit N/A —
1942 PA5364 two-component response regulator PA5364 AlphaFold –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
0.805 No Hit N/A —
1943 PA5358 4-hydroxybenzoate octaprenyltransferase ubiA, PA5358 AlphaFold
2.5.1.39
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008412Catalysis of the reaction: 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. +36 total
0.805 Hit 40.1% 1.08e-27
1944 PA5228 5-formyltetrahydrofolate cyclo-ligase PA5228 AlphaFold
6.3.3.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0030272Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.805 Hit 27.0% 9.01e-15
1945 PA5061 hypothetical protein PA5061 AlphaFold – – 0.805 No Hit N/A —
1946 PA4333 fumarase PA4333 AlphaFold
4.2.1.2
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. GO:0046872Binding to a metal ion. +36 total
0.805 No Hit N/A —
1947 PA3811 co-chaperone HscB PA3811, hscB AlphaFold –
GO:1990230A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor), which may be a target protein or another Fe-S assembly complex. In humans, it consists of HSPA9, HSCB, GLRX5, ABCB7 and GFER. GO:0001671Binds to and increases the activity of an ATP hydrolysis activity. GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. +36 total
0.805 Hit 35.2% 1.89e-07
1948 PA2685 hypothetical protein vgrG1c, PA2685 AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033104A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
0.805 No Hit N/A —
1949 PA1787 aconitate hydratase B PA1787, acnB AlphaFold
4.2.1.3 4.2.1.99
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0047456Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H2O. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +69 total
0.805 No Hit N/A —
1950 PA1231 hypothetical protein PA1231 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.805 No Hit N/A —
Page of 223 · 5572 total proteins