Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2876 KP13_05060 putative glycosyltransferase AlphaFold DB model + ColabFold model – – No map 0.51 No Hit 0.0% —
2877 KP13_01983 Ubiquinol-cytochrome c chaperone AlphaFold DB model + ColabFold model – – No map 0.51 No Hit 0.0% —
2878 KP13_00371 Maltose transport system permease protein malF malF AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990060Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. +25 total
No map 0.51 No Hit 0.0% —
2879 KP13_04975 Acyl-coenzyme A thioesterase paaI paaI AlphaFold DB model + ColabFold model –
GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. GO:0016289Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+.
No map 0.509 No Hit 0.0% —
2880 KP13_00934 Polyphosphate kinase ppk AlphaFold DB model + ColabFold model
2.7.4.1
GO:0009358A protein complex that possesses polyphosphate kinase activity. GO:0008976Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
No map 0.509 No Hit 0.0% —
2881 KP13_32159 tRNA/rRNA methyltransferase LasT AlphaFold DB model + ColabFold model
2.1.1.200
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
No map 0.508 No Hit 0.0% —
2882 KP13_03839 Transaldolase A talA AlphaFold DB model + ColabFold model
2.2.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004801Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. +25 total
No map 0.508 Hit 60.9% 3.51e-112
2883 KP13_01123 putative phospholipid ABC transporter-binding protein mlaB mlaB AlphaFold DB model + ColabFold model – – No map 0.508 No Hit 0.0% —
2884 KP13_00513 Fumarate reductase iron-sulfur subunit frdB AlphaFold DB model + ColabFold model
1.3.5.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +811 total
No map 0.508 Hit 37.2% 8.45e-11
2885 KP13_00473 Biofilm PGA synthesis lipoprotein pgaB pgaB AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0043708The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
No map 0.508 No Hit 0.0% —
2886 KP13_05157 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.507 No Hit 0.0% —
2887 KP13_03899 Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase puuC AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0004030Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
No map 0.507 Hit 54.3% 1.09e-07
2888 KP13_02867 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.507 No Hit 0.0% —
2889 KP13_02843 Cob(I)yrinic acid a,c-diamide adenosyltransferase AlphaFold DB model + ColabFold model
2.5.1.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008817Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No map 0.507 Hit 51.2% 8.72e-06
2890 KP13_01788 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.507 No Hit 0.0% —
2891 KP13_31827 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.506 No Hit 0.0% —
2892 KP13_05102 putative vanillate O-demethylase oxidoreductase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +14 total
No map 0.506 No Hit 0.0% —
2893 KP13_04055 RNA-directed DNA polymerase AlphaFold DB model + ColabFold model
2.7.7.49
GO:0006278A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. GO:0003964Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. GO:0003723Binding to an RNA molecule or a portion thereof. +25 total
No map 0.506 No Hit 0.0% —
2894 KP13_01735 Sec-independent protein translocase protein tatB tatB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043953The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. GO:0008320Enables the transfer of a protein from one side of a membrane to the other. +14 total
No map 0.506 No Hit 0.0% —
2895 KP13_00990 NADH-quinone oxidoreductase subunit E nuoE AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. +25 total
No map 0.506 Hit 35.0% 6.27e-27
2896 KP13_00968 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.506 No Hit 0.0% —
2897 KP13_00873 phage modification methylase MunI munIM AlphaFold DB model + ColabFold model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.506 No Hit 0.0% —
2898 KP13_06687 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.505 No Hit 0.0% —
2899 KP13_04907 Thiamine kinase thiK AlphaFold DB model + ColabFold model
2.7.1.89
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0019165Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate. GO:0006772The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. +25 total
No map 0.505 No Hit 0.0% —
2900 KP13_04625 Pyruvate kinase I pykF AlphaFold DB model + ColabFold model
2.7.1.40
GO:0030955Binding to a potassium ion (K+). GO:0000287Binding to a magnesium (Mg) ion. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
No map 0.505 Hit 56.4% 7.25e-09
Page of 208 · 5192 total proteins