Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
276 KP13_00453 Protein phnJ phnJ AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
0.282 No Hit 0.0% —
277 KP13_00454 Protein phnI phnI AlphaFold + ColabFold –
GO:0019634The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
0.536 No Hit 0.0% —
278 KP13_00455 Protein phnH phnH AlphaFold + ColabFold –
GO:0019634The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.668 No Hit 0.0% —
279 KP13_00456 Protein phnG phnG AlphaFold + ColabFold –
GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0019634The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.64 No Hit 0.0% —
280 KP13_00457 putative transcriptional regulator phnF phnF AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.099 No Hit 0.0% —
281 KP13_00459 Protein phnA phnA AlphaFold + ColabFold – – 0.65 No Hit 0.0% —
282 KP13_00460 hypothetical protein ColabFold – – 0.871 No Hit 0.0% —
283 KP13_00462 Melibiose operon regulatory protein melR AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.435 No Hit 0.0% —
284 KP13_00463 Alpha-galactosidase melA AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
0.331 No Hit 0.0% —
285 KP13_00465 Plasmid segregation protein parM parM AlphaFold + ColabFold – – 0.628 No Hit 0.0% —
286 KP13_00466 Plasmid stability protein stbB stbB AlphaFold + ColabFold – – 0.284 No Hit 0.0% —
287 KP13_00467 Chaperone modulatory protein cbpM cbpM AlphaFold + ColabFold – – 0.129 No Hit 0.0% —
288 KP13_00469 TerC family integral membrane protein terC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.518 No Hit 0.0% —
289 KP13_00470 putative protein-folding factor DsbA dsbA AlphaFold + ColabFold – – 0.303 No Hit 0.0% —
290 KP13_00471 putative biofilm PGA synthesis protein pgaD pgaD AlphaFold + ColabFold –
GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.925 No Hit 0.0% —
291 KP13_00473 Biofilm PGA synthesis lipoprotein pgaB pgaB AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0043708The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.508 No Hit 0.0% —
292 KP13_00474 Biofilm PGA synthesis protein pgaA pgaA AlphaFold + ColabFold –
GO:1901515Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other. GO:0005515Binding to a protein.
0.239 No Hit 0.0% —
293 KP13_00476 hypothetical protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.983 No Hit 0.0% —
294 KP13_00477 PerC transcriptional activator perC AlphaFold + ColabFold – – No pocket No Hit 0.0% —
295 KP13_00478 hypothetical protein AlphaFold + ColabFold – – 0.111 No Hit 0.0% —
296 KP13_00479 hypothetical protein ColabFold – – 0.501 No Hit 0.0% —
297 KP13_00480 hypothetical protein ColabFold – – 0.726 No Hit 0.0% —
298 KP13_00481 hypothetical protein AlphaFold + ColabFold – – 0.807 No Hit 0.0% —
299 KP13_00482 hypothetical protein AlphaFold + ColabFold – – 0.2 No Hit 0.0% —
300 KP13_00483 hypothetical protein AlphaFold + ColabFold – – 0.243 No Hit 0.0% —
Page of 234 · 5842 total proteins