Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3151 KP13_03391 plasmid stabilization system, cytotoxic translational repressor protein AlphaFold + ColabFold – – 0.515 No Hit 0.0% —
3152 KP13_01871 S-adenosylmethionine decarboxylase proenzyme speD AlphaFold + ColabFold
4.1.1.50
GO:0008295The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. GO:0004014Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.515 No Hit 0.0% —
3153 KP13_01621 Holliday junction ATP-dependent DNA helicase ruvA ruvA AlphaFold + ColabFold –
GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0009379A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA. +811 total
0.515 No Hit 0.0% —
3154 KP13_01464 Glutamyl-tRNA reductase hemA AlphaFold + ColabFold
1.2.1.70
GO:0008883Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. +14 total
0.515 No Hit 0.0% —
3155 KP13_01218 L-ribulose-5-phosphate 3-epimerase ulaE ulaE AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. GO:0034015Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate. +14 total
0.515 No Hit 0.0% —
3156 KP13_00432 Inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.515 No Hit 0.0% —
3157 KP13_32187 Proline porter II AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.514 No Hit 0.0% —
3158 KP13_04804 Type IV secretion system protein virB10 virB10 AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.514 No Hit 0.0% —
3159 KP13_04516 Pca regulon regulatory protein pcaR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.514 No Hit 0.0% —
3160 KP13_01562 Cell division topological specificity factor minE AlphaFold + ColabFold –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0032955Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0042802Binding to an identical protein or proteins.
0.514 No Hit 0.0% —
3161 KP13_31957 hypothetical protein ColabFold – – 0.513 No Hit 0.0% —
3162 KP13_05507 hypothetical protein AlphaFold + ColabFold – – 0.513 No Hit 0.0% —
3163 KP13_04759 tellurite resistance YeaR-type protein AlphaFold + ColabFold – – 0.513 No Hit 0.0% —
3164 KP13_04629 Cysteine desulfurase bifunctional protein sufS AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. GO:0006534OBSOLETE. The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. +14 total
0.513 Hit 32.1% 5.47e-07
3165 KP13_04167 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.513 No Hit 0.0% —
3166 KP13_03672 Peptidyl-prolyl cis-trans isomerase D ppiD AlphaFold + ColabFold –
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.513 No Hit 0.0% —
3167 KP13_03656 hypothetical protein AlphaFold + ColabFold – – 0.513 No Hit 0.0% —
3168 KP13_03128 Beta-lactamase CTX-M-2 blaCTX AlphaFold + ColabFold
3.5.2.6
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +14 total
0.513 No Hit 0.0% —
3169 KP13_02562 hypothetical protein AlphaFold + ColabFold
3.2.1.78
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005515Binding to a protein. +25 total
0.513 No Hit 0.0% —
3170 KP13_01367 2-iminoacetate synthase thiH AlphaFold + ColabFold
4.1.99.19
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005506Binding to an iron (Fe) ion. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.513 No Hit 0.0% —
3171 KP13_32088 DNA topoisomerase III topB AlphaFold + ColabFold
5.6.2.1
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. GO:0003917Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. +69 total
0.512 Hit 22.1% 9.60e-19
3172 KP13_32059 Protein TrhZ AlphaFold + ColabFold – – 0.512 No Hit 0.0% —
3173 KP13_05191 D-allulose-6-phosphate 3-epimerase AlphaFold + ColabFold
5.1.3.-
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0034700Catalysis of the reaction: D-allulose 6-phosphate = keto-D-fructose 6-phosphate. GO:0046872Binding to a metal ion. +69 total
0.512 Hit 33.7% 2.31e-27
3174 KP13_04639 Multidrug resistance protein mdtA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.512 No Hit 0.0% —
3175 KP13_04087 hypothetical protein AlphaFold + ColabFold – – 0.512 No Hit 0.0% —
Page of 234 · 5842 total proteins