Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3176 KP13_02861 Transcriptional regulator lsrR lsrR AlphaFold + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
0.512 No Hit 0.0% —
3177 KP13_02312 Propanediol utilization protein pduA pduA AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
0.512 No Hit 0.0% —
3178 KP13_12038 Lipopolysaccharide export system permease protein lptF lptF Experimental + AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.511 No Hit 0.0% —
3179 KP13_05574 hypothetical protein AlphaFold + ColabFold – – 0.511 No Hit 0.0% —
3180 KP13_05031 Fumarate nitrate reduction regulatory protein fnr AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +58 total
0.511 No Hit 0.0% —
3181 KP13_04938 hypothetical protein AlphaFold + ColabFold – – 0.511 No Hit 0.0% —
3182 KP13_03889 putative diguanylate phosphodiesterase AlphaFold + ColabFold –
GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
0.511 No Hit 0.0% —
3183 KP13_03012 hypothetical protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016413Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. +14 total
0.511 No Hit 0.0% —
3184 KP13_02728 Protein sprT sprT AlphaFold + ColabFold – – 0.511 No Hit 0.0% —
3185 KP13_01854 Poly(A) polymerase pcnB AlphaFold + ColabFold
2.7.7.19
GO:0006378OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. GO:1990817Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). +58 total
0.511 Hit 43.1% 6.25e-06
3186 KP13_00718 hypothetical protein AlphaFold + ColabFold – – 0.511 No Hit 0.0% —
3187 KP13_00277 Cyclic di-GMP-binding protein bcsB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006011The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.511 No Hit 0.0% —
3188 KP13_31912 hypothetical protein ColabFold – – 0.51 No Hit 0.0% —
3189 KP13_16917 ATP-dependent DNA helicase rep rep AlphaFold + ColabFold
5.6.2.4
GO:0006268OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +1013 total
0.51 No Hit 0.0% —
3190 KP13_05060 putative glycosyltransferase AlphaFold + ColabFold – – 0.51 No Hit 0.0% —
3191 KP13_01983 Ubiquinol-cytochrome c chaperone AlphaFold + ColabFold – – 0.51 No Hit 0.0% —
3192 KP13_00371 Maltose transport system permease protein malF malF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990060Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. +25 total
0.51 No Hit 0.0% —
3193 KP13_04975 Acyl-coenzyme A thioesterase paaI paaI AlphaFold + ColabFold –
GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. GO:0016289Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+.
0.509 No Hit 0.0% —
3194 KP13_00934 Polyphosphate kinase ppk AlphaFold + ColabFold
2.7.4.1
GO:0009358A protein complex that possesses polyphosphate kinase activity. GO:0008976Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.509 No Hit 0.0% —
3195 KP13_32159 tRNA/rRNA methyltransferase LasT AlphaFold + ColabFold
2.1.1.200
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.508 No Hit 0.0% —
3196 KP13_03839 Transaldolase A talA AlphaFold + ColabFold
2.2.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004801Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. +25 total
0.508 Hit 60.9% 3.51e-112
3197 KP13_01123 putative phospholipid ABC transporter-binding protein mlaB mlaB AlphaFold + ColabFold – – 0.508 No Hit 0.0% —
3198 KP13_00513 Fumarate reductase iron-sulfur subunit frdB AlphaFold + ColabFold
1.3.5.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +811 total
0.508 Hit 37.2% 8.45e-11
3199 KP13_00473 Biofilm PGA synthesis lipoprotein pgaB pgaB AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0043708The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.508 No Hit 0.0% —
3200 KP13_32122 insertion sequence IS1 ColabFold – – 0.507 No Hit 0.0% —
Page of 234 · 5842 total proteins