Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3976 KP13_32184 oligoribonuclease AlphaFold + ColabFold
3.1.-.-
GO:0003676Binding to a nucleic acid. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.317 Hit 58.7% 3.85e-12
3977 KP13_06701 hypothetical protein AlphaFold + ColabFold – – 0.317 No Hit 0.0% —
3978 KP13_05024 hypothetical protein AlphaFold + ColabFold – – 0.317 No Hit 0.0% —
3979 KP13_02987 putative oxaloacetate decarboxylase gamma chain oadG AlphaFold + ColabFold
7.2.4.2
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015081Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. GO:0036376The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. +36 total
0.317 No Hit 0.0% —
3980 KP13_02262 sn-glycerol-3-phosphate import ATP-binding protein UgpC ugpC AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.317 Hit 32.6% 1.14e-16
3981 KP13_01775 hypothetical protein AlphaFold + ColabFold – – 0.317 No Hit 0.0% —
3982 KP13_01102 Ribosome maturation factor rimP rimP AlphaFold + ColabFold –
GO:0042274A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
0.317 No Hit 0.0% —
3983 KP13_00620 GTP-binding protein typA/bipA typA AlphaFold + ColabFold
3.6.5.-
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +811 total
0.317 Hit 58.3% 9.89e-12
3984 KP13_31638 putative L-aspartate dehydrogenase nadX AlphaFold + ColabFold
1.4.1.21
GO:0033735Catalysis of the reaction: Catalysis of the reaction: L-aspartate + NAD(P)+ + H2O = oxaloacetate + NH4+ + NADPH + H+. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. +36 total
0.316 No Hit 0.0% —
3985 KP13_04078 hypothetical protein AlphaFold + ColabFold – – 0.316 No Hit 0.0% —
3986 KP13_04016 hypothetical protein AlphaFold + ColabFold – – 0.316 No Hit 0.0% —
3987 KP13_03575 Lipid A biosynthesis lauroyl acyltransferase htrB AlphaFold + ColabFold
2.3.1.241
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. +47 total
0.316 No Hit 0.0% —
3988 KP13_03143 putative chaperone protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140662Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
0.316 Hit 24.8% 8.11e-06
3989 KP13_00719 putative adenosine monophosphate-protein transferase fic fic AlphaFold + ColabFold
2.7.7.108
GO:0070733Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051302Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.
0.316 No Hit 0.0% —
3990 KP13_00591 Rhamnulokinase rhaB AlphaFold + ColabFold
2.7.1.5
GO:0019301The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
0.316 No Hit 0.0% —
3991 KP13_31807 Copper resistance protein C AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0006825The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005507Binding to a copper (Cu) ion. +25 total
0.315 No Hit 0.0% —
3992 KP13_31554 hypothetical protein AlphaFold + ColabFold – – 0.315 No Hit 0.0% —
3993 KP13_05217 Methionine aminopeptidase AlphaFold + ColabFold
3.4.11.18
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.315 Hit 44.3% 1.35e-59
3994 KP13_04786 hypothetical protein AlphaFold + ColabFold –
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0051607Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
0.315 No Hit 0.0% —
3995 KP13_04590 renal dipeptidase (rDP)-related protein AlphaFold + ColabFold –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0070573Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.315 Hit 28.3% 9.28e-08
3996 KP13_04504 flavin reductase domain-containing protein AlphaFold + ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016646Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.315 No Hit 0.0% —
3997 KP13_04019 hypothetical protein AlphaFold + ColabFold – – 0.315 No Hit 0.0% —
3998 KP13_03339 Penicillin-binding protein 2 mrdA AlphaFold + ColabFold
3.4.16.4
GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. +69 total
0.315 No Hit 0.0% —
3999 KP13_02571 putative hydrogenase nickel incorporation protein hypA hypA AlphaFold + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0051604Any process leading to the attainment of the full functional capacity of a protein. GO:0016530Binding to and delivering metal ions to a target protein. +14 total
0.315 No Hit 0.0% —
4000 KP13_02068 hypothetical protein AlphaFold + ColabFold – – 0.315 No Hit 0.0% —
Page of 208 · 5192 total proteins