Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4051 KP13_04142 hypothetical protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
0.381 No Hit 0.0% —
4052 KP13_03934 Transcriptional regulator, LysR family ColabFold – – 0.381 No Hit 0.0% —
4053 KP13_03807 Protein-tyrosine-phosphatase in cps region wzb AlphaFold + ColabFold
3.1.3.48
GO:0004725Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. GO:0006470The process of removing one or more phosphoric residues from a protein.
0.381 Hit 39.4% 1.46e-06
4054 KP13_03793 Uridine diphosphate galacturonate 4-epimerase in cps region uge-1 AlphaFold + ColabFold – – 0.381 Hit 36.2% 4.24e-19
4055 KP13_01188 Thiamine biosynthesis lipoprotein apbE AlphaFold + ColabFold
2.7.1.180
GO:0017013The addition of a flavin group to a protein amino acid. GO:0046872Binding to a metal ion. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.381 No Hit 0.0% —
4056 KP13_00133 putative drug/metabolite transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.381 No Hit 0.0% —
4057 KP13_31841 hypothetical protein AlphaFold + ColabFold – – 0.38 No Hit 0.0% —
4058 KP13_06138 Thiol:disulfide interchange protein dsbA AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. +14 total
0.38 No Hit 0.0% —
4059 KP13_04178 Beta-lactamase-like protein AlphaFold + ColabFold
1.6.3.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.38 No Hit 0.0% —
4060 KP13_04011 Lysis protein S from lambdoid prophage Qin essQ AlphaFold + ColabFold –
GO:0001907A process mediated by a symbiont that results in the death of a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. GO:0140911An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.
0.38 No Hit 0.0% —
4061 KP13_02697 Dihydroxy-acid dehydratase ilvD AlphaFold + ColabFold
4.2.1.9
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0004160Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +69 total
0.38 No Hit 0.0% —
4062 KP13_01258 GCN5-related N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.38 No Hit 0.0% —
4063 KP13_05490 Flavodoxin-like fold family protein AlphaFold + ColabFold
1.6.5.- 1.7.1.17
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +14 total
0.379 No Hit 0.0% —
4064 KP13_05220 Chaperone protein lpfB lpfB AlphaFold + ColabFold –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
0.379 No Hit 0.0% —
4065 KP13_04067 Isochorismatase-like protein AlphaFold + ColabFold
3.-.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.379 No Hit 0.0% —
4066 KP13_02273 HTH-type transcriptional regulator galR galR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.379 No Hit 0.0% —
4067 KP13_01320 Protein iolH ioH AlphaFold + ColabFold – – 0.379 No Hit 0.0% —
4068 KP13_00092 2-aminoethylphosphonate--pyruvate transaminase phnW AlphaFold + ColabFold
2.6.1.37
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0047304Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde.
0.379 Hit 25.6% 1.20e-20
4069 KP13_32190 putative putrescine/spermidine ABC transporter ATPase AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +14 total
0.378 Hit 34.7% 2.23e-22
4070 KP13_31543 tRNA modification GTPase mnmE mnmE AlphaFold + ColabFold
3.6.-.-
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0005515Binding to a protein. +58 total
0.378 Hit 40.7% 5.77e-30
4071 KP13_05537 Fructose-like phosphotransferase enzyme IIB component AlphaFold + ColabFold –
GO:0022877Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
0.378 No Hit 0.0% —
4072 KP13_05494 Acyl-CoA N-acyltransferase domain-containing protein AlphaFold + ColabFold – – 0.378 No Hit 0.0% —
4073 KP13_05038 hypothetical protein AlphaFold + ColabFold –
GO:0004520Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks.
0.378 No Hit 0.0% —
4074 KP13_05036 Indole-3-acetyl-aspartic acid hydrolase iaaH Experimental + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.378 No Hit 0.0% —
4075 KP13_02370 L-serine dehydratase 2 sdaB AlphaFold + ColabFold
4.3.1.17
GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. +25 total
0.378 No Hit 0.0% —
Page of 234 · 5842 total proteins