Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4176 KP13_04326 HTH-type transcriptional regulator perR perR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.499 No Hit 0.0% —
4177 KP13_04327 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.863 No Hit 0.0% —
4178 KP13_04328 putative membrane protein AlphaFold DB model + ColabFold model – – No map 0.401 No Hit 0.0% —
4179 KP13_04331 Inner membrane transport permease AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.867 No Hit 0.0% —
4180 KP13_04332 Inner membrane transport permease AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +14 total
No map 0.787 No Hit 0.0% —
4181 KP13_04333 putative Inner membrane protein AlphaFold DB model + ColabFold model – – No map 0.988 No Hit 0.0% —
4182 KP13_04334 hypothetical protein ColabFold model – – No map 0.498 No Hit 0.0% —
4183 KP13_04335 Endonuclease/exonuclease/phosphatase AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No map 0.335 No Hit 0.0% —
4184 KP13_04336 Putative cardiolipin synthase AlphaFold DB model + ColabFold model
2.7.8.-
GO:0032049The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008808Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. +14 total
No map 0.947 No Hit 0.0% —
4185 KP13_04337 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.994 No Hit 0.0% —
4186 KP13_04338 putative type VI secretion system protein AlphaFold DB model + ColabFold model – – No map 0.257 No Hit 0.0% —
4187 KP13_04339 DotU family type VI secretion system protein AlphaFold DB model + ColabFold model – – No map 0.341 No Hit 0.0% —
4188 KP13_04340 OmpA/MotB domain-containing protein Experimental + AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.656 No Hit 0.0% —
4189 KP13_04341 Hcp family type VI secretion system protein AlphaFold DB model + ColabFold model – – No map 0.2 No Hit 0.0% —
4190 KP13_04343 Type VI secretion system Vgr family protein AlphaFold DB model + ColabFold model – – No map 0.932 No Hit 0.0% —
4191 KP13_04344 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.31 No Hit 0.0% —
4192 KP13_04345 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.335 No Hit 0.0% —
4193 KP13_04347 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.874 No Hit 0.0% —
4194 KP13_04349 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.46 No Hit 0.0% —
4195 KP13_04350 PaaR repeat-containing lipoprotein AlphaFold DB model + ColabFold model – – No map No pocket No Hit 0.0% —
4196 KP13_04351 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.596 No Hit 0.0% —
4197 KP13_04352 IcmF-related domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.975 No Hit 0.0% —
4198 KP13_04353 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.429 No Hit 0.0% —
4199 KP13_04354 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.132 No Hit 0.0% —
4200 KP13_04355 hypothetical protein ColabFold model – – No map 0.602 No Hit 0.0% —
Page of 234 · 5842 total proteins