Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4776 KP13_02751 hypothetical protein AlphaFold + ColabFold – – 0.152 No Hit 0.0% —
4777 KP13_02545 hypothetical protein AlphaFold + ColabFold – – 0.152 No Hit 0.0% —
4778 KP13_01457 Cation transport regulator chaB chaB AlphaFold + ColabFold – – 0.152 No Hit 0.0% —
4779 KP13_01275 Antitoxin RelB relB AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template.
0.152 No Hit 0.0% —
4780 KP13_01083 putative NADH dehydrogenase AlphaFold + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.152 Hit 30.0% 5.22e-25
4781 KP13_05152 hypothetical protein AlphaFold + ColabFold – – 0.151 No Hit 0.0% —
4782 KP13_04990 Glutamate dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016639Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +47 total
0.151 Hit 49.3% 2.32e-20
4783 KP13_03550 Glucose-specific phosphotransferase enzyme IIA component crr AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.151 No Hit 0.0% —
4784 KP13_00839 hypothetical protein AlphaFold + ColabFold – – 0.151 No Hit 0.0% —
4785 KP13_04819 hypothetical protein AlphaFold + ColabFold – – 0.15 No Hit 0.0% —
4786 KP13_04753 putative tautomerase AlphaFold + ColabFold – – 0.15 No Hit 0.0% —
4787 KP13_03117 hypothetical protein AlphaFold + ColabFold – – 0.15 No Hit 0.0% —
4788 KP13_02794 hypothetical protein AlphaFold + ColabFold – – 0.15 No Hit 0.0% —
4789 KP13_00778 Trk system potassium uptake protein trkA trkA AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015079Enables the transfer of potassium ions (K+) from one side of a membrane to the other. GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.15 No Hit 0.0% —
4790 KP13_00279 putative cellulose synthase operon protein D AlphaFold + ColabFold –
GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
0.15 No Hit 0.0% —
4791 KP13_04482 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.149 No Hit 0.0% —
4792 KP13_04193 hypothetical protein AlphaFold + ColabFold – – 0.149 No Hit 0.0% —
4793 KP13_02695 Acetolactate synthase isozyme 2 small subunit ilvM AlphaFold + ColabFold – – 0.149 No Hit 0.0% —
4794 KP13_01864 Hypoxanthine phosphoribosyltransferase hpt AlphaFold + ColabFold
2.4.2.8
GO:0006166Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. GO:0004422Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +710 total
0.149 Hit 35.1% 4.05e-26
4795 KP13_01493 hypothetical protein AlphaFold + ColabFold – – 0.149 No Hit 0.0% —
4796 KP13_32199 hypothetical protein AlphaFold + ColabFold – – 0.147 No Hit 0.0% —
4797 KP13_16060 Alanine racemase domain-containing protein AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.147 No Hit 0.0% —
4798 KP13_05447 Psp operon transcriptional activator pspF AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.147 No Hit 0.0% —
4799 KP13_04790 NAD(P)-binding domain-containing protein AlphaFold + ColabFold –
GO:0008641Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0061503Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A. +14 total
0.147 No Hit 0.0% —
4800 KP13_01853 Glutamyl-Q tRNA(Asp) synthetase gluQ AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +47 total
0.147 Hit 36.9% 4.51e-38
Page of 208 · 5192 total proteins