Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4826 KP13_02025 GCN5-related N-acetyltransferase AlphaFold + ColabFold
2.3.1.266
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006474The acetylation of the N-terminal amino acid of proteins. +25 total
0.14 Hit 38.6% 9.59e-08
4827 KP13_03910 Flavoprotein wrbA wrbA AlphaFold + ColabFold
1.6.5.2
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. +69 total
0.139 No Hit 0.0% —
4828 KP13_02802 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
0.139 No Hit 0.0% —
4829 KP13_31949 hypothetical protein AlphaFold + ColabFold – – 0.138 No Hit 0.0% —
4830 KP13_04400 putative ABC transporter system permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.138 No Hit 0.0% —
4831 KP13_00882 hypothetical protein AlphaFold + ColabFold – – 0.138 No Hit 0.0% —
4832 KP13_00217 Putative L-lactate dehydrogenase operon regulatory protein lldR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.138 No Hit 0.0% —
4833 KP13_02313 Propanediol utilization protein PduH pduH AlphaFold + ColabFold – – 0.136 No Hit 0.0% —
4834 KP13_01755 ATPase domain-containing protein AlphaFold + ColabFold –
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872Binding to a metal ion.
0.136 No Hit 0.0% —
4835 KP13_01153 hypothetical protein AlphaFold + ColabFold – – 0.136 No Hit 0.0% —
4836 KP13_02636 hypothetical protein AlphaFold + ColabFold – – 0.135 No Hit 0.0% —
4837 KP13_02195 Tyrosine recombinase xerD xerD AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0009009Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences. +69 total
0.135 No Hit 0.0% —
4838 KP13_01881 Pyruvate dehydrogenase complex repressor pdhR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.135 No Hit 0.0% —
4839 KP13_00266 Ankyrin repeat domain-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein.
0.135 Hit 38.6% 4.07e-06
4840 KP13_05475 TIM barrel domain-containing protein AlphaFold + ColabFold – – 0.134 No Hit 0.0% —
4841 KP13_02359 hypothetical protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. +58 total
0.134 No Hit 0.0% —
4842 KP13_31860 hypothetical protein AlphaFold + ColabFold – – 0.133 No Hit 0.0% —
4843 KP13_04297 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.133 Hit 38.7% 4.19e-18
4844 KP13_03393 hypothetical protein AlphaFold + ColabFold – – 0.133 No Hit 0.0% —
4845 KP13_02973 HTH-type transcriptional activator aaeR aaeR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.133 No Hit 0.0% —
4846 KP13_02855 Autoinducer 2-degrading protein lsrG lsrG AlphaFold + ColabFold
5.3.1.32
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002952Catalysis of the reaction: (2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.133 No Hit 0.0% —
4847 KP13_01848 Type 4 prepilin-like proteins leader peptide-processing enzyme bifunctional protein pulO AlphaFold + ColabFold
2.1.1.- 3.4.23.43
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
0.133 No Hit 0.0% —
4848 KP13_31874 putative cobalt-precorrin-6Y C(5)-methyltransferase cbiE AlphaFold + ColabFold –
GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +14 total
0.132 No Hit 0.0% —
4849 KP13_06667 hypothetical protein AlphaFold + ColabFold – – 0.132 No Hit 0.0% —
4850 KP13_05276 Multiple antibiotic resistance protein marA marA AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.132 No Hit 0.0% —
Page of 208 · 5192 total proteins