Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5276 KP13_06619 hypothetical protein AlphaFold + ColabFold – – 0.171 No Hit 0.0% —
5277 KP13_04728 putative glucose-6-phosphate 1-epimerase AlphaFold + ColabFold
5.1.3.15
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +36 total
0.171 No Hit 0.0% —
5278 KP13_03302 Protein seqA seqA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0032297Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.171 No Hit 0.0% —
5279 KP13_05784 hypothetical protein AlphaFold + ColabFold –
GO:0043022Binding to a ribosome. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.17 No Hit 0.0% —
5280 KP13_03908 Glucose-1-phosphatase agp AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0050308Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.
0.17 No Hit 0.0% —
5281 KP13_32399 hypothetical protein ColabFold – – 0.169 No Hit 0.0% —
5282 KP13_04534 hypothetical protein ColabFold – – 0.169 No Hit 0.0% —
5283 KP13_03961 ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.169 Hit 24.2% 2.19e-08
5284 KP13_00405 Anti-adapter protein iraM iraM AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009267Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
0.169 No Hit 0.0% —
5285 KP13_04650 hypothetical protein AlphaFold + ColabFold – – 0.168 No Hit 0.0% —
5286 KP13_02693 putative ATP-dependent protease AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.168 Hit 23.9% 4.34e-07
5287 KP13_01590 Tail-specific protease prc AlphaFold + ColabFold
3.4.21.102
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +47 total
0.168 No Hit 0.0% —
5288 KP13_02214 Arsenate reductase arsC AlphaFold + ColabFold
1.20.4.1
GO:0008794Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. GO:0046685Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
0.167 No Hit 0.0% —
5289 KP13_01195 putative acid phosphatase AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0050308Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.
0.167 Hit 31.5% 7.20e-06
5290 KP13_00896 PBSX phage terminase small subunit AlphaFold + ColabFold –
GO:0051276A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
0.167 No Hit 0.0% —
5291 KP13_00539 23S rRNA (guanosine-2'-O-)-methyltransferase rlmB rlmB AlphaFold + ColabFold
2.1.1.185
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +36 total
0.167 Hit 30.5% 2.58e-18
5292 KP13_00288 Endoglucanase bcsZ AlphaFold + ColabFold
3.2.1.4
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0008810Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. +14 total
0.167 No Hit 0.0% —
5293 KP13_31589 hypothetical protein ColabFold – – 0.166 No Hit 0.0% —
5294 KP13_02912 putative hydrolase AlphaFold + ColabFold
3.1.1.1
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0106435Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.
0.166 No Hit 0.0% —
5295 KP13_02290 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.166 No Hit 0.0% —
5296 KP13_01270 metal-dependent hydrolase AlphaFold + ColabFold –
GO:0019213Catalysis of the hydrolysis of an acetyl group from a substrate molecule. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. +14 total
0.166 No Hit 0.0% —
5297 KP13_01267 hypothetical protein AlphaFold + ColabFold – – 0.166 No Hit 0.0% —
5298 KP13_01017 Lysine-arginine-ornithine-binding periplasmic protein argT AlphaFold + ColabFold –
GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.166 No Hit 0.0% —
5299 KP13_31588 putative alpha/beta-Hydrolases superfamily protein AlphaFold + ColabFold – – 0.165 No Hit 0.0% —
5300 KP13_03802 putative glycosyltransferase in cps region AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.165 No Hit 0.0% —
Page of 234 · 5842 total proteins