Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5251 KP13_02167 Ribose-5-phosphate isomerase A rpiA AlphaFold + ColabFold
5.3.1.6
GO:0009052The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. GO:0004751Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.176 Hit 37.1% 8.58e-31
5252 KP13_02034 YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein AlphaFold + ColabFold –
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA.
0.176 No Hit 0.0% —
5253 KP13_00284 hypothetical protein AlphaFold + ColabFold – – 0.176 No Hit 0.0% —
5254 KP13_05585 hypothetical protein AlphaFold + ColabFold – – 0.175 No Hit 0.0% —
5255 KP13_03874 Protein sxy sxy AlphaFold + ColabFold –
GO:0030420The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.
0.175 No Hit 0.0% —
5256 KP13_03055 putative Type VI secretion system effector AlphaFold + ColabFold – – 0.175 No Hit 0.0% —
5257 KP13_02759 Glucose/ribitol dehydrogenase family protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.175 Hit 24.9% 7.55e-06
5258 KP13_01863 Carbonic anhydrase 2 can AlphaFold + ColabFold –
GO:0004089Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. GO:0008270Binding to a zinc ion (Zn). GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.
0.175 No Hit 0.0% —
5259 KP13_31893 Enterobactin synthase component F entF AlphaFold + ColabFold –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0031177Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
0.174 Hit 28.9% 3.75e-06
5260 KP13_04729 NADPH-dependent oxidoreductase Experimental + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.174 Hit 36.0% 9.41e-06
5261 KP13_04361 hypothetical protein AlphaFold + ColabFold – – 0.174 No Hit 0.0% —
5262 KP13_01164 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
0.174 No Hit 0.0% —
5263 KP13_04241 hypothetical protein AlphaFold + ColabFold – – 0.173 No Hit 0.0% —
5264 KP13_03465 PTS family sugar transport protein component IIA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
0.173 No Hit 0.0% —
5265 KP13_03080 F-type conjugal transfer protein TraV ColabFold – – 0.173 No Hit 0.0% —
5266 KP13_02467 putative outer membrane protein AlphaFold + ColabFold – – 0.173 No Hit 0.0% —
5267 KP13_02130 fimbrillin matB matB AlphaFold + ColabFold –
GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
0.173 No Hit 0.0% —
5268 KP13_01242 Lactose permease AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005351Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).
0.173 No Hit 0.0% —
5269 KP13_00659 Thermoresistant gluconokinase gntK AlphaFold + ColabFold
2.7.1.12
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.173 Hit 54.3% 1.82e-08
5270 KP13_31569 Protein dcrB dcrB AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.172 No Hit 0.0% —
5271 KP13_02777 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.172 No Hit 0.0% —
5272 KP13_02142 Gamma-glutamyl phosphate reductase proA AlphaFold + ColabFold
1.2.1.41
GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004350Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH. +47 total
0.172 Hit 36.2% 2.64e-82
5273 KP13_01400 hypothetical protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.172 No Hit 0.0% —
5274 KP13_00134 NUDIX hydrolase protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006753The chemical reactions and pathways involving any phosphorylated nucleoside. +14 total
0.172 No Hit 0.0% —
5275 KP13_31772 30S ribosomal protein S12 AlphaFold + ColabFold –
GO:0015935The smaller of the two subunits of a ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +36 total
0.171 Hit 48.2% 1.22e-28
Page of 234 · 5842 total proteins