Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5251 KP13_00363 LpxA-like domain-containing transferase AlphaFold DB model + ColabFold model – – No map 0.049 0.258 No Hit 0.0% —
5252 KP13_04144 Tellurium resistance protein terZ terZ AlphaFold DB model + ColabFold model –
GO:0046690Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus.
No map 0.048 0.216 No Hit 0.0% —
5253 KP13_04049 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.048 0.767 No Hit 0.0% —
5254 KP13_03334 DNA polymerase III subunit delta holA AlphaFold DB model + ColabFold model
2.7.7.7
GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +25 total
No map 0.048 0.622 No Hit 0.0% —
5255 KP13_01810 Elongation factor Ts tsf AlphaFold DB model + ColabFold model –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0005515Binding to a protein. GO:0006414The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. +14 total
No map 0.048 0.664 Hit 36.1% 3.51e-12
5256 KP13_00908 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.048 0.745 No Hit 0.0% —
5257 KP13_00008 D-ribose pyranase rbsD AlphaFold DB model + ColabFold model
5.4.99.62
GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0048029Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. +47 total
No map 0.048 0.366 No Hit 0.0% —
5258 KP13_32380 DNA-binding transcriptional regulator LrhA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.047 0.155 No Hit 0.0% —
5259 KP13_03619 Recombination protein recR recR AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0046872Binding to a metal ion. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
No map 0.047 0.969 No Hit 0.0% —
5260 KP13_02283 RNA pyrophosphohydrolase rppH AlphaFold DB model + ColabFold model
3.6.1.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034353Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end. +14 total
No map 0.047 0.19 No Hit 0.0% —
5261 KP13_00533 Protein hflC hflC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0052547Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +14 total
No map 0.047 0.367 Hit 28.1% 7.97e-07
5262 KP13_32010 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.046 0.481 No Hit 0.0% —
5263 KP13_06667 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.046 0.132 No Hit 0.0% —
5264 KP13_04845 putative lipoprotein Experimental + ColabFold model – – No map 0.046 0.382 No Hit 0.0% —
5265 KP13_03581 two-component regulatory system response regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.046 0.498 No Hit 0.0% —
5266 KP13_02978 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.046 No Hit 0.0% —
5267 KP13_02222 acyltransferase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.046 0.365 No Hit 0.0% —
5268 KP13_02034 YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein AlphaFold DB model + ColabFold model –
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA.
No map 0.046 0.176 No Hit 0.0% —
5269 KP13_01580 putative inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005384Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.
No map 0.046 0.463 No Hit 0.0% —
5270 KP13_01447 hypothetical protein ColabFold model – – No map 0.046 0.973 No Hit 0.0% —
5271 KP13_00951 hypothetical protein ColabFold model – – No map 0.046 0.444 No Hit 0.0% —
5272 KP13_00436 TPR-like domain-containing protein Experimental + ColabFold model –
GO:0005515Binding to a protein.
No map 0.046 0.343 No Hit 0.0% —
5273 KP13_31934 capsule synthesis regulatory protein B ColabFold model – – No map 0.045 0.63 No Hit 0.0% —
5274 KP13_12908 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.045 0.477 No Hit 0.0% —
5275 KP13_05143 Superoxide dismutase Fe sodB AlphaFold DB model + ColabFold model
1.15.1.1
GO:0004784Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +25 total
No map 0.045 0.051 Hit 58.3% 2.27e-07
Page of 234 · 5842 total proteins