Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5226 KP13_02028 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.053 0.743 No Hit 0.0% —
5227 KP13_01443 Mercuric resistance operon regulatory protein merR AlphaFold DB model + ColabFold model –
GO:0045340Binding to a mercury ion (Hg2+). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.053 0.638 No Hit 0.0% —
5228 KP13_01168 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.053 0.459 No Hit 0.0% —
5229 KP13_00783 Protein smg smg AlphaFold DB model + ColabFold model – – No map 0.053 0.569 No Hit 0.0% —
5230 KP13_00766 30S ribosomal protein S5 rpsE AlphaFold DB model + ColabFold model –
GO:0015935The smaller of the two subunits of a ribosome. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +25 total
No map 0.053 0.26 Hit 29.2% 4.60e-08
5231 KP13_06654 DNA replication terminus site-binding protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006274The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.052 0.263 No Hit 0.0% —
5232 KP13_05026 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.052 0.591 No Hit 0.0% —
5233 KP13_03245 PKD domain-containing protein ColabFold model – – No map 0.052 0.906 No Hit 0.0% —
5234 KP13_03090 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.052 0.392 No Hit 0.0% —
5235 KP13_06638 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.051 No Hit 0.0% —
5236 KP13_05136 Riboflavin synthase alpha chain ribE AlphaFold DB model + ColabFold model
2.5.1.9
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004746Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
No map 0.051 0.27 No Hit 0.0% —
5237 KP13_03355 Universal stress protein G AlphaFold DB model + ColabFold model – – No map 0.051 0.539 No Hit 0.0% —
5238 KP13_03003 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0071468Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
No map 0.051 0.077 No Hit 0.0% —
5239 KP13_31802 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.050 0.414 No Hit 0.0% —
5240 KP13_05433 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI Experimental + ColabFold model
1.3.1.9
GO:0004318Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
No map 0.050 0.532 Hit 30.9% 2.07e-07
5241 KP13_03442 putative binding-protein-dependent transport system protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +25 total
No map 0.050 0.641 No Hit 0.0% —
5242 KP13_02349 putative inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.050 0.5 No Hit 0.0% —
5243 KP13_00681 Carboxylesterase bioH bioH Experimental + ColabFold model –
GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0052689Catalysis of the hydrolysis of a carboxylic ester bond.
No map 0.050 0.553 Hit 30.2% 2.30e-06
5244 KP13_00119 Antibiotic efflux pump outer membrane protein AlphaFold DB model + ColabFold model –
GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.050 0.554 No Hit 0.0% —
5245 KP13_32055 F-type conjugal transfer protein TraU AlphaFold DB model + ColabFold model – – No map 0.049 0.687 No Hit 0.0% —
5246 KP13_13105 Thioredoxin-1 trxA AlphaFold DB model + ColabFold model –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell.
No map 0.049 0.179 Hit 41.9% 9.27e-18
5247 KP13_06647 hypothetical protein ColabFold model – – No map 0.049 0.451 No Hit 0.0% —
5248 KP13_04476 putative transporter protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.049 0.946 No Hit 0.0% —
5249 KP13_01902 Cell division protein ftsQ ftsQ AlphaFold DB model + ColabFold model –
GO:0090529The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.049 0.438 No Hit 0.0% —
5250 KP13_01845 General secretion pathway protein L AlphaFold DB model + ColabFold model –
GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. +14 total
No map 0.049 0.733 No Hit 0.0% —
Page of 234 · 5842 total proteins