Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5226 KP13_00803 ATP-dependent RNA helicase srmB srmB AlphaFold + ColabFold
3.6.4.13
GO:0000027The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +36 total
0.181 Hit 56.5% 2.92e-14
5227 KP13_05440 Peptide transport periplasmic protein sapA sapA AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
0.18 No Hit 0.0% —
5228 KP13_05213 putative oxidoreductase, Fe-S subunit AlphaFold + ColabFold –
GO:0016788Catalysis of the hydrolysis of any ester bond.
0.18 No Hit 0.0% —
5229 KP13_03737 hypothetical protein ColabFold – – 0.18 No Hit 0.0% —
5230 KP13_13105 Thioredoxin-1 trxA AlphaFold + ColabFold –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell.
0.179 Hit 41.9% 9.27e-18
5231 KP13_31930 transposase insD for insertion element IS2I AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.178 No Hit 0.0% —
5232 KP13_31637 DNAase like-I protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
0.178 No Hit 0.0% —
5233 KP13_25163 3-oxoadipate CoA-transferase subunit A pcal AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.178 Hit 48.2% 4.02e-21
5234 KP13_05661 L-asparaginase 1 ansA AlphaFold + ColabFold
3.5.1.1
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004067Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH4+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.178 Hit 58.6% 6.13e-34
5235 KP13_05515 Aminotransferase, class V domain-containing protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008453Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. GO:0004760Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. +14 total
0.178 Hit 33.0% 1.63e-64
5236 KP13_04107 hypothetical protein AlphaFold + ColabFold – – 0.178 No Hit 0.0% —
5237 KP13_03657 hypothetical protein AlphaFold + ColabFold – – 0.178 No Hit 0.0% —
5238 KP13_03469 Sugar isomerase (SIS) domain-containing protein AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. +36 total
0.178 Hit 26.0% 2.61e-09
5239 KP13_03406 Ferric enterobactin transport ATP-binding protein fepC fepC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.178 Hit 32.0% 3.42e-15
5240 KP13_01503 transposase insD for insertion sequence element IS2 insD7 AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.178 No Hit 0.0% —
5241 KP13_31740 putative antitoxin in type II toxin-antitoxin system ColabFold – – 0.177 No Hit 0.0% —
5242 KP13_04794 hypothetical protein ColabFold – – 0.177 No Hit 0.0% —
5243 KP13_04791 hypothetical protein AlphaFold + ColabFold –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.177 No Hit 0.0% —
5244 KP13_04105 hypothetical protein AlphaFold + ColabFold – – 0.177 No Hit 0.0% —
5245 KP13_03957 hypothetical protein AlphaFold + ColabFold – – 0.177 No Hit 0.0% —
5246 KP13_03040 Molybdopterin synthase sulfur carrier subunit moaD AlphaFold + ColabFold –
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
0.177 No Hit 0.0% —
5247 KP13_01494 hypothetical protein AlphaFold + ColabFold – – 0.177 No Hit 0.0% —
5248 KP13_01052 hypothetical protein ColabFold – – 0.177 No Hit 0.0% —
5249 KP13_04503 HTH-type transcriptional activator rhaS AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.176 No Hit 0.0% —
5250 KP13_03649 hypothetical protein ColabFold – – 0.176 No Hit 0.0% —
Page of 234 · 5842 total proteins