Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5301 KP13_02129 matC family protein AlphaFold DB model + ColabFold model – – No map 0.042 0.268 No Hit 0.0% —
5302 KP13_32171 hypothetical protein ColabFold model – – No map 0.041 0.603 No Hit 0.0% —
5303 KP13_03774 Histidine biosynthesis bifunctional protein hisIE hisI AlphaFold DB model + ColabFold model –
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0004635Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. GO:0004636Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+. +25 total
No map 0.041 0.367 No Hit 0.0% —
5304 KP13_03230 Nitrogen regulatory protein ptsN AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.041 0.976 No Hit 0.0% —
5305 KP13_03014 HlyD-like secretion protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.041 0.719 No Hit 0.0% —
5306 KP13_02220 oxidoreductase, aldo/keto reductase family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.041 0.562 No Hit 0.0% —
5307 KP13_01649 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.041 0.48 No Hit 0.0% —
5308 KP13_32172 hypothetical protein ColabFold model – – No map N/A 0.04 No Hit 0.0% —
5309 KP13_05556 LysM domain/BON superfamily protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.040 0.055 No Hit 0.0% —
5310 KP13_03215 Stringent starvation protein A sspA AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.040 0.272 Hit 32.2% 3.12e-09
5311 KP13_02518 Multifunctional protein surE surE AlphaFold DB model + ColabFold model
3.1.3.5 3.1.3.6 3.6.1.11
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0008252Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
No map 0.040 0.338 No Hit 0.0% —
5312 KP13_02131 putative HTH-type transcriptional regulator matA matA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.040 0.601 No Hit 0.0% —
5313 KP13_01703 Protein hemY hemY AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515Binding to a protein. GO:0042168The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. +25 total
No map 0.040 0.844 No Hit 0.0% —
5314 KP13_01485 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.040 0.726 No Hit 0.0% —
5315 KP13_00049 DNA polymerase III subunit beta dnaN AlphaFold DB model + ColabFold model –
GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +58 total
No map 0.040 0.232 No Hit 0.0% —
5316 KP13_32103 initiator RepB protein repB AlphaFold DB model + ColabFold model –
GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0006270The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
No map 0.039 0.146 No Hit 0.0% —
5317 KP13_05626 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.039 0.312 No Hit 0.0% —
5318 KP13_05303 putative subunit of heme lyase AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
No map N/A 0.039 No Hit 0.0% —
5319 KP13_04040 putative phage tail protein AlphaFold DB model + ColabFold model – – No map 0.039 0.652 No Hit 0.0% —
5320 KP13_04019 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.039 0.315 No Hit 0.0% —
5321 KP13_03605 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.039 0.407 No Hit 0.0% —
5322 KP13_02664 putative transmembrane protein AlphaFold DB model + ColabFold model – – No map 0.039 0.836 No Hit 0.0% —
5323 KP13_02417 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.039 0.295 No Hit 0.0% —
5324 KP13_05145 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.038 No Hit 0.0% —
5325 KP13_04810 type IV secretion system VirB5 component AlphaFold DB model + ColabFold model – – No map 0.038 0.4 No Hit 0.0% —
Page of 234 · 5842 total proteins