Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5476 KP13_04809 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.024 0.222 No Hit 0.0% —
5477 KP13_03921 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.024 0.63 No Hit 0.0% —
5478 KP13_02193 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.024 0.027 No Hit 0.0% —
5479 KP13_01894 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000917The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. +14 total
No map 0.024 0.68 No Hit 0.0% —
5480 KP13_01650 Ferritin-1 ftnA AlphaFold DB model + ColabFold model
1.16.3.2
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0006879A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +47 total
No map 0.024 0.587 No Hit 0.0% —
5481 KP13_01300 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.024 0.575 No Hit 0.0% —
5482 KP13_01288 RutC family protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
No map 0.024 0.201 Hit 47.4% 4.98e-18
5483 KP13_00759 hypothetical protein ColabFold model – – No map 0.024 0.413 No Hit 0.0% —
5484 KP13_00454 Protein phnI phnI AlphaFold DB model + ColabFold model –
GO:0019634The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
No map 0.024 0.536 No Hit 0.0% —
5485 KP13_31772 30S ribosomal protein S12 AlphaFold DB model + ColabFold model –
GO:0015935The smaller of the two subunits of a ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +36 total
No map 0.023 0.171 Hit 48.2% 1.22e-28
5486 KP13_06747 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.023 0.198 No Hit 0.0% —
5487 KP13_05469 putative ABC transporter permease protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.023 0.712 No Hit 0.0% —
5488 KP13_05376 Acyl-CoA thioester hydrolase AlphaFold DB model + ColabFold model –
GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0052816Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. +25 total
No map 0.023 0.261 Hit 31.9% 1.87e-06
5489 KP13_05109 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.023 0.632 No Hit 0.0% —
5490 KP13_04802 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.023 0.468 No Hit 0.0% —
5491 KP13_04587 Coenzyme PQQ synthesis protein D pqqD AlphaFold DB model + ColabFold model –
GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
No map 0.023 0.42 No Hit 0.0% —
5492 KP13_04251 Putrescine transport system permease protein potI potI AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.023 0.931 No Hit 0.0% —
5493 KP13_04129 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.023 0.467 No Hit 0.0% —
5494 KP13_03911 hypothetical protein ColabFold model – – No map N/A 0.023 No Hit 0.0% —
5495 KP13_02640 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.023 0.574 No Hit 0.0% —
5496 KP13_02637 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.023 0.648 No Hit 0.0% —
5497 KP13_02113 Ethanolamine ammonia-lyase light chain AlphaFold DB model + ColabFold model
4.3.1.7
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0009350An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. +36 total
No map 0.023 0.482 No Hit 0.0% —
5498 KP13_01846 General secretion pathway protein M pulM AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.023 0.361 No Hit 0.0% —
5499 KP13_31899 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.022 0.8 No Hit 0.0% —
5500 KP13_06640 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.022 0.805 No Hit 0.0% —
Page of 234 · 5842 total proteins