Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5451 KP13_03460 Transcriptional activator ramA ramA Experimental + AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.027 0.267 No Hit 0.0% —
5452 KP13_01774 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.027 0.649 No Hit 0.0% —
5453 KP13_01669 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.027 0.315 No Hit 0.0% —
5454 KP13_00726 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.027 0.414 No Hit 0.0% —
5455 KP13_32400 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.026 No Hit 0.0% —
5456 KP13_31889 Cold shock-like protein CspE cspE AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map N/A 0.026 Hit 60.0% 6.40e-07
5457 KP13_05017 DNA replication terminus site-binding protein tus AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006274The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.026 0.646 No Hit 0.0% —
5458 KP13_04056 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.026 0.836 No Hit 0.0% —
5459 KP13_03471 RNA polymerase sigma factor 54, interaction domain-containing protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.026 0.736 No Hit 0.0% —
5460 KP13_02922 Na(+)-translocating NADH-quinone reductase subunit D nqrD AlphaFold DB model + ColabFold model
7.2.1.1
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. +25 total
No map 0.026 0.807 No Hit 0.0% —
5461 KP13_01822 Iron--sulfur cluster insertion protein erpA erpA AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.026 0.63 Hit 45.8% 1.13e-19
5462 KP13_00688 Transcriptional regulatory protein ompR ompR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
No map 0.026 0.363 No Hit 0.0% —
5463 KP13_00671 Thiosulfate sulfurtransferase glpE glpE AlphaFold DB model + ColabFold model
2.8.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0103041Catalysis of the reaction: thiosulfate + [thioredoxin]-dithiol = sulfite + 2 H+ + [thioredoxin]-disulfide + hydrogen sulfide.
No map 0.026 0.405 No Hit 0.0% —
5464 KP13_25184 3-carboxy-cis,cis-muconate cycloisomerase pcaB AlphaFold DB model + ColabFold model
5.5.1.2
GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0047472Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+. +14 total
No map 0.025 0.55 Hit 30.3% 3.22e-10
5465 KP13_04576 hypothetical protein ColabFold model – – No map N/A 0.025 No Hit 0.0% —
5466 KP13_04531 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.025 No Hit 0.0% —
5467 KP13_04187 Chromosome partition protein mukF mukF AlphaFold DB model + ColabFold model –
GO:0005509Binding to a calcium ion (Ca2+). GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
No map 0.025 0.889 No Hit 0.0% —
5468 KP13_02888 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.025 0.857 No Hit 0.0% —
5469 KP13_02183 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016209Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
No map 0.025 0.282 No Hit 0.0% —
5470 KP13_01546 Endo-type membrane-bound lytic murein transglycosylase A emtA AlphaFold DB model + ColabFold model
4.2.2.n1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000270The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. +25 total
No map 0.025 0.82 No Hit 0.0% —
5471 KP13_01139 Small heat shock protein ibp ibp AlphaFold DB model + ColabFold model – – No map 0.025 0.357 No Hit 0.0% —
5472 KP13_31606 Protein phnB phnB AlphaFold DB model + ColabFold model – – No map 0.024 0.32 No Hit 0.0% —
5473 KP13_05302 putative subunit of heme lyase AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.024 0.906 No Hit 0.0% —
5474 KP13_05074 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.024 0.196 No Hit 0.0% —
5475 KP13_04882 putative ribose-5-phosphate isomerase B AlphaFold DB model + ColabFold model
5.3.1.6
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004751Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate.
No map 0.024 0.283 No Hit 0.0% —
Page of 234 · 5842 total proteins