Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5501 KP13_05169 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.022 0.856 No Hit 0.0% —
5502 KP13_03716 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.022 0.575 No Hit 0.0% —
5503 KP13_03116 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.022 0.187 No Hit 0.0% —
5504 KP13_02079 Recombination-associated protein rdgC rdgC AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.022 0.463 No Hit 0.0% —
5505 KP13_02031 Membrane-associated diguanylate cyclase AlphaFold DB model + ColabFold model
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +25 total
No map 0.022 0.688 No Hit 0.0% —
5506 KP13_01705 Uroporphyrinogen-III synthase hemD AlphaFold DB model + ColabFold model
4.2.1.75
GO:0006780The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0004852Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III. +14 total
No map 0.022 0.575 No Hit 0.0% —
5507 KP13_01559 YcgL domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.022 0.544 No Hit 0.0% —
5508 KP13_01380 Zinc resistance-associated protein zraP AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.022 0.038 No Hit 0.0% —
5509 KP13_00892 hypothetical protein ColabFold model – – No map 0.022 0.331 No Hit 0.0% —
5510 KP13_32013 hypothetical protein ColabFold model – – No map 0.021 0.792 No Hit 0.0% —
5511 KP13_05149 Lactoylglutathione lyase gloA AlphaFold DB model + ColabFold model
4.4.1.5
GO:0004462Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. GO:0046872Binding to a metal ion. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.021 0.282 Hit 35.9% 1.03e-23
5512 KP13_04908 fibronectin-binding protein AlphaFold DB model + ColabFold model –
GO:0031241The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +14 total
No map 0.021 0.579 No Hit 0.0% —
5513 KP13_04408 Elongation factor P-like protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0043043The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. +25 total
No map N/A 0.021 No Hit 0.0% —
5514 KP13_04099 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.021 0.684 No Hit 0.0% —
5515 KP13_03236 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase kdsC Experimental + ColabFold model
3.1.3.45
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0019143Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. GO:0046872Binding to a metal ion. +25 total
No map 0.021 0.287 Hit 32.3% 1.04e-18
5516 KP13_03180 hypothetical protein Experimental + AlphaFold DB model + ColabFold model – – No map 0.021 0.479 No Hit 0.0% —
5517 KP13_03153 Transcriptional regulatory protein baeR baeR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
No map 0.021 0.076 No Hit 0.0% —
5518 KP13_02651 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.021 0.527 No Hit 0.0% —
5519 KP13_02553 Iron transport system periplasmic binding component SitA sitA AlphaFold DB model + ColabFold model –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0046872Binding to a metal ion. +14 total
No map 0.021 0.356 No Hit 0.0% —
5520 KP13_01198 hypothetical protein ColabFold model – – No map 0.021 0.227 No Hit 0.0% —
5521 KP13_01040 hypothetical protein AlphaFold DB model + ColabFold model
3.1.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks. GO:0019843Binding to a ribosomal RNA. +14 total
No map 0.021 0.211 No Hit 0.0% —
5522 KP13_00405 Anti-adapter protein iraM iraM AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009267Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
No map 0.021 0.169 No Hit 0.0% —
5523 KP13_31964 hypothetical protein ColabFold model – – No map 0.020 0.993 No Hit 0.0% —
5524 KP13_05263 putative HTH-type transcriptional regulator Experimental + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.020 0.331 No Hit 0.0% —
5525 KP13_05172 Electron transport complex protein rnfG rnfG AlphaFold DB model + ColabFold model
7.-.-.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. +25 total
No map 0.020 0.296 No Hit 0.0% —
Page of 234 · 5842 total proteins