Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 / 5842 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
726 KP13_03835 Protein aegA aegA AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +25 total
No map 0.931 0.937 Hit 29.6% 4.96e-08
727 KP13_02942 putative MFS general substrate transporter AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.931 0.926 No Hit 0.0% —
728 KP13_01523 Phosphoenolpyruvate carboxykinase ATP AlphaFold DB model + ColabFold model
4.1.1.49
GO:0017076Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. +47 total
No map 0.931 0.36 No Hit 0.0% —
729 KP13_00240 Xylose isomerase xylA AlphaFold DB model + ColabFold model
5.3.1.5
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0009045Catalysis of the reaction: alpha-D-xylose = alpha-D-xylulofuranose. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.931 0.452 No Hit 0.0% —
730 KP13_00140 Zinc-type alcohol dehydrogenase-like protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.931 0.238 Hit 34.2% 3.45e-25
731 KP13_04586 Coenzyme PQQ synthesis protein E pqqE AlphaFold DB model + ColabFold model
1.21.98.4
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +710 total
No map 0.930 0.536 No Hit 0.0% —
732 KP13_04140 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion.
No map 0.930 0.086 No Hit 0.0% —
733 KP13_03319 (Dimethylallyl)adenosine tRNA methylthiotransferase miaB miaB AlphaFold DB model + ColabFold model
2.8.4.3
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0035596Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +69 total
No map 0.929 0.045 Hit 35.8% 2.39e-86
734 KP13_01296 putative amidohydrolase AlphaFold DB model + ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
No map 0.929 0.481 No Hit 0.0% —
735 KP13_01010 Epimerase family protein AlphaFold DB model + ColabFold model – – No map 0.929 0.829 Hit 47.8% 2.33e-10
736 KP13_31620 Starvation-sensing protein rspB rspB AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn).
No map 0.928 0.536 Hit 41.5% 8.97e-12
737 KP13_04366 NmrA-like family domain-containing protein 1 AlphaFold DB model + ColabFold model – – No map 0.928 0.194 Hit 36.5% 2.68e-19
738 KP13_01818 Deoxyguanosinetriphosphate triphosphohydrolase dgt AlphaFold DB model + ColabFold model
3.1.5.1
GO:0016793Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. GO:0008832Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate. GO:0006203The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. +14 total
No map 0.928 0.646 No Hit 0.0% —
739 KP13_01088 SCP2 sterol-binding domain-containing protein AlphaFold DB model + ColabFold model –
GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.928 0.965 No Hit 0.0% —
740 KP13_31803 glycine cleavage system aminomethyltransferase T gcvT AlphaFold DB model + ColabFold model –
GO:0006546The chemical reactions and pathways resulting in the breakdown of glycine. GO:0005515Binding to a protein. GO:0004047Catalysis of the reaction: N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4+.
No map 0.927 0.944 Hit 34.2% 1.99e-39
741 KP13_31540 Aspartate--ammonia ligase asnA AlphaFold DB model + ColabFold model
6.3.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004071Catalysis of the reaction: ATP + L-aspartate + NH4+ = AMP + diphosphate + L-asparagine. GO:0006529OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. +36 total
No map 0.927 0.391 No Hit 0.0% —
742 KP13_04591 putative epoxide hydrolase protein Experimental + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No map 0.927 0.786 Hit 33.3% 1.63e-11
743 KP13_03353 Ribonuclease I rna AlphaFold DB model + ColabFold model –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0033897Catalysis of the reaction: a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H+. This reaction is a two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. GO:0006401The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
No map 0.927 0.778 No Hit 0.0% —
744 KP13_01791 tRNA(Ile)-lysidine synthase tilS AlphaFold DB model + ColabFold model
6.3.4.19
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016879Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +47 total
No map 0.927 0.65 No Hit 0.0% —
745 KP13_31499 Cytidylate kinase cmk AlphaFold DB model + ColabFold model
2.7.4.25
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004127OBSOLETE. Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. GO:0006139Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. +58 total
No map 0.926 0.592 No Hit 0.0% —
746 KP13_05529 N-Acetyltransferase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.926 0.018 No Hit 0.0% —
747 KP13_05360 putative hydroxypyruvate reductase ttuD AlphaFold DB model + ColabFold model –
GO:0008887Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.926 0.477 Hit 44.1% 1.01e-38
748 KP13_05308 Heme exporter protein C ccmC AlphaFold DB model + ColabFold model –
GO:0015232Enables the transfer of heme from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015886The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map 0.926 0.877 No Hit 0.0% —
749 KP13_05288 hypothetical protein ColabFold model – – No map N/A 0.926 No Hit 0.0% —
750 KP13_04823 Yersiniabactin biosynthesis thioesterase AlphaFold DB model + ColabFold model –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008610The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
No map 0.926 0.992 Hit 27.5% 4.28e-10
Page of 234 · 5842 total proteins