Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
726 KP13_05397 N-succinylglutamate 5-semialdehyde dehydrogenase AlphaFold + ColabFold
1.2.1.71
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +36 total
0.901 Hit 34.4% 1.37e-06
727 KP13_02509 YfaZ family protein AlphaFold + ColabFold – – 0.901 No Hit 0.0% —
728 KP13_01160 Anaerobic dimethyl sulfoxide reductase chain AlphaFold + ColabFold –
GO:0019645A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009390An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide. +25 total
0.901 No Hit 0.0% —
729 KP13_04841 hypothetical protein AlphaFold + ColabFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +47 total
0.9 No Hit 0.0% —
730 KP13_03503 Aldo/keto reductase family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.9 Hit 34.8% 2.71e-09
731 KP13_01623 putative transcriptional regulatory protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.9 Hit 31.2% 2.73e-32
732 KP13_32150 Transcriptional regulator AcoK AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005515Binding to a protein. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.899 No Hit 0.0% —
733 KP13_31750 RelE family toxin-antitoxin system protein ColabFold – – 0.899 No Hit 0.0% —
734 KP13_01091 luciferase-like monooxygenase AlphaFold + ColabFold –
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.899 No Hit 0.0% —
735 KP13_00823 Phosphoribosylformylglycinamidine synthase purL AlphaFold + ColabFold
6.3.5.3
GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0004642Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.899 Hit 46.5% 1.55e-06
736 KP13_00621 hypothetical protein ColabFold – – 0.899 No Hit 0.0% —
737 KP13_04139 hypothetical protein AlphaFold + ColabFold – – 0.898 No Hit 0.0% —
738 KP13_01898 Secretion monitor secM AlphaFold + ColabFold –
GO:0045182Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.898 No Hit 0.0% —
739 KP13_01075 hypothetical protein AlphaFold + ColabFold – – 0.898 No Hit 0.0% —
740 KP13_05548 ABC transporter permease family AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.897 No Hit 0.0% —
741 KP13_04508 N-hydroxyarylamine O-acetyltransferase nhoA AlphaFold + ColabFold
2.3.1.118
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0004060Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. GO:0046990Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine.
0.897 Hit 26.3% 1.09e-17
742 KP13_04015 hypothetical protein AlphaFold + ColabFold – – 0.897 No Hit 0.0% —
743 KP13_03135 putative phosphatidic acid phosphatase protein in cps region AlphaFold + ColabFold – – 0.897 No Hit 0.0% —
744 KP13_02966 Rod shape-determining protein mreB mreB AlphaFold + ColabFold –
GO:0000902The developmental process in which the size or shape of a cell is generated and organized. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.897 Hit 29.6% 9.89e-08
745 KP13_02811 Glycerol-3-phosphate acyltransferase plsY AlphaFold + ColabFold
2.3.1.275
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. GO:0043772Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate.
0.897 No Hit 0.0% —
746 KP13_00369 protein psiE psiE AlphaFold + ColabFold –
GO:0016036Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.897 No Hit 0.0% —
747 KP13_00353 Acetate operon repressor iclR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.897 No Hit 0.0% —
748 KP13_31488 PTS system N-acetylglucosamine-specific EIICBA component nagE AlphaFold + ColabFold –
GO:0019866The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. GO:0015572Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +69 total
0.896 No Hit 0.0% —
749 KP13_04606 Putative 3-hydroxyphenylpropionic acid transporter mhpT AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.896 Hit 36.6% 8.24e-07
750 KP13_03002 6-phosphogluconolactonase pgl Experimental + ColabFold –
GO:0006098The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005515Binding to a protein. +14 total
0.896 No Hit 0.0% —
Page of 234 · 5842 total proteins