Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
751 KP13_02372 LOG family protein AlphaFold + ColabFold
3.2.2.10 3.2.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008714Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. GO:0047405Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine.
0.896 No Hit 0.0% —
752 KP13_02213 Arsenic efflux pump protein arsB AlphaFold + ColabFold –
GO:0015105Enables the transfer of arsenite from one side of a membrane to the other. GO:0015700The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
0.896 No Hit 0.0% —
753 KP13_01322 putative sn-glycerol-3-phosphate-binding periplasmic protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.896 No Hit 0.0% —
754 KP13_00708 Phosphoglycolate phosphatase gph AlphaFold + ColabFold
3.1.3.18
GO:0008967Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.896 No Hit 0.0% —
755 KP13_00035 Putative outer membrane porin bglH bglH AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219The process in which a carbohydrate is transported across a membrane. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. +58 total
0.896 No Hit 0.0% —
756 KP13_05350 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.895 No Hit 0.0% —
757 KP13_05261 Glutaminase glsA AlphaFold + ColabFold
3.5.1.2
GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0006541The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. GO:0006537OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. +14 total
0.895 Hit 45.3% 2.72e-22
758 KP13_04404 Inner membrane protein AlphaFold + ColabFold
2.7.4.29
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0050380Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate. +36 total
0.895 No Hit 0.0% —
759 KP13_03796 dTDP-4-dehydrorhamnose reductase in cps region rmlD Experimental + ColabFold
1.1.1.133
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008831Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +25 total
0.895 Hit 34.2% 7.45e-15
760 KP13_02681 hypothetical protein AlphaFold + ColabFold – – 0.895 No Hit 0.0% —
761 KP13_31969 Type IV secretion system protein IcmF (I-T4SS) AlphaFold + ColabFold – – 0.894 No Hit 0.0% —
762 KP13_31808 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase AlphaFold + ColabFold
2.1.1.14
GO:0008270Binding to a zinc ion (Zn). GO:0003871Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +36 total
0.894 No Hit 0.0% —
763 KP13_04896 Transcription-repair-coupling factor mfd AlphaFold + ColabFold
3.6.4.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0003684Binding to damaged DNA. +69 total
0.894 No Hit 0.0% —
764 KP13_04445 Aryl-alcohol dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.894 Hit 49.4% 5.33e-16
765 KP13_04302 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.894 Hit 31.8% 1.25e-09
766 KP13_04294 HTH transcriptional regulator, LacI lacI AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.894 No Hit 0.0% —
767 KP13_03351 putative bacterial antimicrobial peptide resistance protein PagP pagP AlphaFold + ColabFold
2.3.1.251
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016409Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.
0.894 No Hit 0.0% —
768 KP13_03001 Phosphatase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.894 No Hit 0.0% —
769 KP13_02900 Dihydrolipoamide acetyltransferase AlphaFold + ColabFold
2.3.1.-
GO:0045254A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0006086The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH.
0.894 Hit 43.5% 9.17e-74
770 KP13_01716 Protein rarD rarD AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.894 No Hit 0.0% —
771 KP13_00563 putative inner membrane transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.894 No Hit 0.0% —
772 KP13_06665 RepAC1 protein (modular protein) repAC1 AlphaFold + ColabFold – – 0.893 No Hit 0.0% —
773 KP13_03895 putative transporter protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +14 total
0.893 No Hit 0.0% —
774 KP13_03757 GGDEF domain-containing protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
0.893 No Hit 0.0% —
775 KP13_01905 undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase murG AlphaFold + ColabFold
2.4.1.227
GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0050511Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamm-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H+ + UDP. +710 total
0.893 No Hit 0.0% —
Page of 234 · 5842 total proteins