Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1051 KP13_01723 Lysophospholipase L2 pldB AlphaFold DB model + ColabFold model
3.1.1.5
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004622Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
No map 0.889 0.989 No Hit 0.0% —
1052 KP13_01217 3-keto-L-gulonate-6-phosphate decarboxylase ulaD ulaD AlphaFold DB model + ColabFold model
4.1.1.85
GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0004590Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP. GO:0033982Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2. +14 total
No map 0.889 0.656 No Hit 0.0% —
1053 KP13_05468 ABC superfamily ATP binding cassette transporter AlphaFold DB model + ColabFold model –
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
No map 0.888 0.223 No Hit 0.0% —
1054 KP13_04642 putative HTH-type transcriptional regulator ltrA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.888 0.753 No Hit 0.0% —
1055 KP13_04508 N-hydroxyarylamine O-acetyltransferase nhoA AlphaFold DB model + ColabFold model
2.3.1.118
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0004060Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. GO:0046990Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine.
No map 0.888 0.897 Hit 26.3% 1.09e-17
1056 KP13_02721 putative MFS general substrate transporter ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.888 0.921 No Hit 0.0% —
1057 KP13_02488 Malate/L-lactate dehydrogenase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.888 0.203 No Hit 0.0% —
1058 KP13_01567 putative ATP-dependent helicase AlphaFold DB model + ColabFold model
5.6.2.3
GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003676Binding to a nucleic acid. +811 total
No map 0.888 0.57 No Hit 0.0% —
1059 KP13_01468 putative sulfate transporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008272OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.888 0.391 Hit 35.2% 8.40e-23
1060 KP13_01207 actin-like ATPase domain-containing protein ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.888 0.388 Hit 32.7% 8.40e-06
1061 KP13_01000 Phosphatase AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion. GO:0043136Catalysis of the reaction: H2O + sn-glycerol 3-phosphate = glycerol + phosphate. GO:0050308Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.
No map 0.888 0.789 Hit 30.1% 6.07e-17
1062 KP13_00978 Menaquinone-specific isochorismate synthase menF AlphaFold DB model + ColabFold model
5.4.4.2
GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008909Catalysis of the reaction: chorismate = isochorismate. +14 total
No map 0.888 0.887 No Hit 0.0% —
1063 KP13_00555 Acetylglutamate kinase argB AlphaFold DB model + ColabFold model
2.7.2.8
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0003991Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate. +25 total
No map 0.888 0.386 No Hit 0.0% —
1064 KP13_31947 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase AlphaFold DB model + ColabFold model
1.1.1.127
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008678Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +14 total
No map 0.887 0.491 Hit 37.7% 8.25e-09
1065 KP13_31822 LysR family regulatory protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.887 0.618 No Hit 0.0% —
1066 KP13_31756 sodium/glutamate symporter gltS AlphaFold DB model + ColabFold model –
GO:0015501Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015813The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore. +14 total
No map 0.887 0.803 No Hit 0.0% —
1067 KP13_05370 PKHD-type hydroxylase AlphaFold DB model + ColabFold model –
GO:0005506Binding to an iron (Fe) ion. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0031418Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. +14 total
No map 0.887 0.621 No Hit 0.0% —
1068 KP13_04599 Putative aliphatic sulfonates-binding protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.887 0.531 No Hit 0.0% —
1069 KP13_03949 UvrABC system protein B AlphaFold DB model + ColabFold model –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0006289A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). +47 total
No map 0.887 0.495 Hit 29.9% 5.15e-07
1070 KP13_02889 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.887 No Hit 0.0% —
1071 KP13_02576 Formate hydrogenlyase subunit 5 hycE AlphaFold DB model + ColabFold model –
GO:0016151Binding to a nickel (Ni) cation. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +36 total
No map 0.887 0.827 Hit 29.9% 8.11e-09
1072 KP13_02555 Fructokinase AlphaFold DB model + ColabFold model –
GO:0004396Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
No map 0.887 0.472 Hit 26.4% 1.19e-16
1073 KP13_02133 Phosphonates-binding periplasmic protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2).
No map 0.887 0.848 No Hit 0.0% —
1074 KP13_00654 putative N-acetyltransferase AlphaFold DB model + ColabFold model
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.887 0.083 No Hit 0.0% —
1075 KP13_00567 Metallo-dependent phosphatase AlphaFold DB model + ColabFold model –
GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. +58 total
No map 0.887 0.692 Hit 31.1% 5.56e-17
Page of 234 · 5842 total proteins