Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5192 proteins Structure: AlphaFold

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: AlphaFold

Search query No active search

Rows per page 25

Rows
Active criteria 1
Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1226 KP13_32126 maltose-inducible porin maltoporin lamB AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0042956The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane. GO:0034219The process in which a carbohydrate is transported across a membrane. +58 total
0.802 No Hit 0.0% —
1227 KP13_31956 putative HTH-type transcription regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.802 No Hit 0.0% —
1228 KP13_04722 Nitrate regulatory protein nasR AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof.
0.802 No Hit 0.0% —
1229 KP13_03275 Succinyl-CoA ligase [ADP-forming] subunit beta sucC AlphaFold + ColabFold
6.2.1.5
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +710 total
0.802 Hit 46.6% 2.88e-111
1230 KP13_31483 30S ribosomal protein S21 rpsU AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.801 No Hit 0.0% —
1231 KP13_04976 Beta-ketoadipyl-CoA thiolase paaJ AlphaFold + ColabFold
2.3.1.174
GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +14 total
0.801 Hit 47.1% 2.95e-59
1232 KP13_04933 Multidrug resistance protein mdtH mdtH AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.801 No Hit 0.0% —
1233 KP13_02306 Ethanolamine utilization protein eutE eutE AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0008774Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.
0.801 Hit 28.1% 7.21e-08
1234 KP13_31899 hypothetical protein AlphaFold + ColabFold – – 0.8 No Hit 0.0% —
1235 KP13_05506 Glutamyl-tRNA(Gln) amidotransferase subunit A gatA AlphaFold + ColabFold
6.3.5.-
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
0.8 Hit 38.7% 3.29e-13
1236 KP13_04558 hypothetical protein AlphaFold + ColabFold – – 0.8 No Hit 0.0% —
1237 KP13_01432 Dihydropteroate synthase type-2 sulII AlphaFold + ColabFold
2.5.1.15
GO:0042558The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. GO:0004156Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. +58 total
0.8 No Hit 0.0% —
1238 KP13_00807 Sigma-E factor negative regulatory protein rseA AlphaFold + ColabFold –
GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.8 No Hit 0.0% —
1239 KP13_00656 putative oxidoreductase AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.8 Hit 31.0% 7.24e-08
1240 KP13_05499 3-oxoacyl-[acyl-carrier-protein] synthase 2 fabF AlphaFold + ColabFold
2.3.1.179
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
0.799 Hit 48.1% 1.78e-10
1241 KP13_03031 hypothetical protein AlphaFold + ColabFold – – 0.799 No Hit 0.0% —
1242 KP13_02199 Lysyl-tRNA synthetase lysS AlphaFold + ColabFold
6.1.1.6
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +912 total
0.799 Hit 53.8% 2.09e-18
1243 KP13_01722 Homoserine/homoserine lactone efflux protein rhtB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.799 No Hit 0.0% —
1244 KP13_01268 hypothetical protein AlphaFold + ColabFold – – 0.799 No Hit 0.0% —
1245 KP13_01089 putative protease AlphaFold + ColabFold –
GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
0.799 No Hit 0.0% —
1246 KP13_31634 Cysteine/O-acetylserine efflux protein eamB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.798 No Hit 0.0% —
1247 KP13_05530 Major facilitator Superfamily protein AlphaFold + ColabFold –
GO:0019531Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0019532The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. +25 total
0.798 Hit 31.5% 2.81e-07
1248 KP13_04314 Ribosomal RNA large subunit methyltransferase F rlmF AlphaFold + ColabFold
2.1.1.181
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008988Catalysis of the reaction: adenosine in rRNA + S-adenosyl-L-methionine = H+ + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +36 total
0.798 Hit 34.4% 2.80e-09
1249 KP13_03837 hypothetical protein AlphaFold + ColabFold – – 0.798 No Hit 0.0% —
1250 KP13_01645 putative symporter AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +14 total
0.798 Hit 29.6% 8.63e-06
Page of 208 · 5192 total proteins