Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1626 KP13_00694 Haloacid dehydrogenase/epoxide hydrolase AlphaFold + ColabFold – – 0.755 No Hit 0.0% —
1627 KP13_04365 hypothetical protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.754 No Hit 0.0% —
1628 KP13_02316 Propanediol dehydratase medium subunit pduD AlphaFold + ColabFold – – 0.754 No Hit 0.0% —
1629 KP13_02211 hypothetical protein AlphaFold + ColabFold – – 0.754 No Hit 0.0% —
1630 KP13_00865 GTP-binding protein engA engA AlphaFold + ColabFold –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0043022Binding to a ribosome. GO:0042254A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
0.754 Hit 27.7% 4.35e-10
1631 KP13_05132 hypothetical protein ColabFold – – 0.753 No Hit 0.0% —
1632 KP13_04995 Succinylglutamate desuccinylase AlphaFold + ColabFold
3.5.1.96
GO:0008270Binding to a zinc ion (Zn). GO:0019545OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate. GO:0009017Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate. +25 total
0.753 No Hit 0.0% —
1633 KP13_04642 putative HTH-type transcriptional regulator ltrA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.753 No Hit 0.0% —
1634 KP13_03030 hypothetical protein AlphaFold + ColabFold – – 0.753 No Hit 0.0% —
1635 KP13_02709 alpha/beta hydrolase fold domain-containing protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.753 Hit 38.9% 1.22e-07
1636 KP13_02144 hypothetical protein ColabFold – – 0.753 No Hit 0.0% —
1637 KP13_00322 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.753 No Hit 0.0% —
1638 KP13_04263 hypothetical protein ColabFold – – 0.752 No Hit 0.0% —
1639 KP13_03885 Sulfurtransferase tusE tusE AlphaFold + ColabFold
2.8.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +14 total
0.752 No Hit 0.0% —
1640 KP13_03451 putative binding-protein-dependent transport system protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.752 No Hit 0.0% —
1641 KP13_02400 Siroheme synthase 1 cysG1 AlphaFold + ColabFold –
GO:0004851Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+. GO:0051266Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
0.752 No Hit 0.0% —
1642 KP13_02192 hypothetical protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034552The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. GO:0006105The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.
0.752 No Hit 0.0% —
1643 KP13_02868 putative oxidoreductase AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.751 Hit 25.9% 1.46e-23
1644 KP13_02344 moeB family protein AlphaFold + ColabFold –
GO:0008641Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
0.751 Hit 33.3% 1.93e-08
1645 KP13_01165 Inner membrane transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.751 Hit 30.0% 3.32e-07
1646 KP13_04868 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.75 No Hit 0.0% —
1647 KP13_03664 Multidrug resistance-like ATP-binding protein MdlA mdlA AlphaFold + ColabFold
7.6.2.2
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
0.75 Hit 50.0% 8.14e-15
1648 KP13_02795 ADP-ribose pyrophosphatase nudF Experimental + ColabFold
3.6.1.13
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0046872Binding to a metal ion. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +69 total
0.75 No Hit 0.0% —
1649 KP13_01508 OmpA domain-containing protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.75 No Hit 0.0% —
1650 KP13_01025 Protein dedA dedA AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.75 No Hit 0.0% —
Page of 234 · 5842 total proteins