Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1826 KP13_04683 kinase-like domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.754 0.96 Hit 43.4% 1.29e-14
1827 KP13_02294 Exodeoxyribonuclease V alpha chain recD AlphaFold DB model + ColabFold model
5.6.2.3
GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. +811 total
No map 0.754 0.712 No Hit 0.0% —
1828 KP13_01155 putative lipoprotein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.754 0.682 No Hit 0.0% —
1829 KP13_00955 DNA gyrase subunit A gyrA AlphaFold DB model + ColabFold model
5.6.2.2
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. +811 total
No map 0.754 0.336 Hit 27.6% 1.59e-15
1830 KP13_32083 putative exonuclease AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0006259Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
No map 0.753 0.331 No Hit 0.0% —
1831 KP13_05132 hypothetical protein ColabFold model – – No map N/A 0.753 No Hit 0.0% —
1832 KP13_04776 Nitrogen assimilation regulatory protein nac nac AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.753 0.386 No Hit 0.0% —
1833 KP13_03030 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.753 No Hit 0.0% —
1834 KP13_02386 GTP pyrophosphokinase relA AlphaFold DB model + ColabFold model
2.7.6.5
GO:0015969The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
No map 0.753 0.911 No Hit 0.0% —
1835 KP13_02017 putative transporter protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005337Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. GO:1901642The directed movement of nucleoside across a membrane. +25 total
No map 0.753 0.769 Hit 39.5% 1.90e-32
1836 KP13_01573 Diguanylate phosphodiesterase domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.753 0.697 No Hit 0.0% —
1837 KP13_00491 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.753 0.761 Hit 26.2% 4.03e-08
1838 KP13_31638 putative L-aspartate dehydrogenase nadX AlphaFold DB model + ColabFold model
1.4.1.21
GO:0033735Catalysis of the reaction: Catalysis of the reaction: L-aspartate + NAD(P)+ + H2O = oxaloacetate + NH4+ + NADPH + H+. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. +36 total
No map 0.752 0.316 No Hit 0.0% —
1839 KP13_06771 ATP-dependent DNA helicase AlphaFold DB model + ColabFold model
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
No map 0.752 0.526 Hit 34.0% 1.19e-66
1840 KP13_04263 hypothetical protein ColabFold model – – No map N/A 0.752 No Hit 0.0% —
1841 KP13_03314 N-acetylglucosamine-6-phosphate deacetylase nagA AlphaFold DB model + ColabFold model –
GO:0006044The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. GO:0008448Catalysis of the reaction: H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +36 total
No map 0.752 0.505 Hit 39.2% 2.11e-13
1842 KP13_00167 DNA ligase B ligB AlphaFold DB model + ColabFold model
6.5.1.2
GO:0003911Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0006259Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. +14 total
No map 0.752 0.836 No Hit 0.0% —
1843 KP13_03478 putative periplasmic binding protein/LacI transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.751 0.925 No Hit 0.0% —
1844 KP13_01967 Dihydrodipicolinate reductase dapB AlphaFold DB model + ColabFold model
1.17.1.8
GO:0008839Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
No map 0.751 0.729 No Hit 0.0% —
1845 KP13_01552 SpoVR family protein AlphaFold DB model + ColabFold model – – No map 0.751 0.593 No Hit 0.0% —
1846 KP13_00710 Siroheme synthase 2 cysG2 AlphaFold DB model + ColabFold model –
GO:0004851Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+. GO:0051266Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +58 total
No map 0.751 0.579 No Hit 0.0% —
1847 KP13_31602 HTH-type transcriptional regulator ilvY ilvY AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.750 0.829 No Hit 0.0% —
1848 KP13_03708 GCN5-related N-acetyltransferase Experimental + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.750 0.932 No Hit 0.0% —
1849 KP13_03495 Histone deacetylase superfamily protein Experimental + ColabFold model
3.5.1.-
GO:0004407Removal of an acetyl group from a lysine residue in a histone. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. +14 total
No map 0.750 0.974 Hit 36.2% 2.04e-35
1850 KP13_03265 Protein tolB tolB AlphaFold DB model + ColabFold model –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0017038The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. +14 total
No map 0.750 0.654 No Hit 0.0% —
Page of 234 · 5842 total proteins