Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1851 KP13_04638 Multidrug resistance protein mdtB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.718 No Hit 0.0% —
1852 KP13_00374 Maltoporin 2 lamB2 AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0042956The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane. GO:0034219The process in which a carbohydrate is transported across a membrane. +710 total
0.718 No Hit 0.0% —
1853 KP13_31594 putative tannase/feruloyl esterase AlphaFold + ColabFold –
GO:0052689Catalysis of the hydrolysis of a carboxylic ester bond. GO:0046872Binding to a metal ion.
0.717 No Hit 0.0% —
1854 KP13_06886 conjugal transfer TrbC-like protein AlphaFold + ColabFold – – 0.717 No Hit 0.0% —
1855 KP13_05128 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.717 No Hit 0.0% —
1856 KP13_01538 Fatty acid desaturase domain-containing protein AlphaFold + ColabFold –
GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
0.717 No Hit 0.0% —
1857 KP13_00915 hypothetical protein AlphaFold + ColabFold – – 0.717 No Hit 0.0% —
1858 KP13_00713 hypothetical protein AlphaFold + ColabFold – – 0.717 No Hit 0.0% —
1859 KP13_00367 putative branched-chain amino acid transport protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903785The directed movement of L-valine across a membrane.
0.717 No Hit 0.0% —
1860 KP13_05286 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0003871Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +14 total
0.716 No Hit 0.0% —
1861 KP13_03200 Phospho-cellobiase casB AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.716 Hit 35.8% 1.54e-10
1862 KP13_02774 hypothetical protein AlphaFold + ColabFold – – 0.716 No Hit 0.0% —
1863 KP13_01752 Multidrug resistance protein mdtM mdtM AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.716 No Hit 0.0% —
1864 KP13_00534 hypothetical protein AlphaFold + ColabFold – – 0.716 No Hit 0.0% —
1865 KP13_00090 Purine ribonucleoside efflux pump nepI nepI AlphaFold + ColabFold –
GO:0015211Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
0.716 No Hit 0.0% —
1866 KP13_05140 hypothetical protein ColabFold – – 0.715 No Hit 0.0% —
1867 KP13_00917 hypothetical protein ColabFold – – 0.715 No Hit 0.0% —
1868 KP13_00699 hypothetical protein AlphaFold + ColabFold – – 0.715 No Hit 0.0% —
1869 KP13_16086 3,4-dihydroxyphenylacetate 2,3-dioxygenase hpcB AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008198Binding to a ferrous iron ion, Fe(II). GO:0008687Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H+. +14 total
0.714 No Hit 0.0% —
1870 KP13_03972 hypothetical protein AlphaFold + ColabFold – – 0.714 No Hit 0.0% —
1871 KP13_03670 Long-chain acyl-CoA thioesterase FadM fadM AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
0.714 No Hit 0.0% —
1872 KP13_02863 2,4-dienoyl-CoA reductase [NADPH] fadH AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0008670Catalysis of the reactions: a 4,5-saturated-(2E)-enoyl-CoA + NADP+ = a (2E,4E)-dienoyl-CoA + H+ + NADPH, and a (2E,4Z)-dienoyl-CoA + H+ + NADPH = a 4,5-saturated-(2E)-enoyl-CoA + NADP+. +36 total
0.714 No Hit 0.0% —
1873 KP13_00070 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.714 No Hit 0.0% —
1874 KP13_32388 hypothetical protein AlphaFold + ColabFold – – 0.713 No Hit 0.0% —
1875 KP13_31609 Thiamine-phosphate synthase thiE AlphaFold + ColabFold
2.5.1.3
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0004789Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H+ = diphosphate + thiamine phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.713 No Hit 0.0% —
Page of 234 · 5842 total proteins