Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1901 KP13_05286 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0003871Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +14 total
No map 0.735 0.716 No Hit 0.0% —
1902 KP13_03755 hypothetical protein ColabFold model – – No map N/A 0.735 No Hit 0.0% —
1903 KP13_00059 hypothetical protein ColabFold model – – No map N/A 0.735 No Hit 0.0% —
1904 KP13_04614 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.734 0.651 No Hit 0.0% —
1905 KP13_03638 50S ribosomal protein L31 type B rpmE2 AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
No map N/A 0.734 No Hit 0.0% —
1906 KP13_03551 Phosphoenolpyruvate-protein phosphotransferase ptsI AlphaFold DB model + ColabFold model
2.7.3.9
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
No map 0.734 0.63 No Hit 0.0% —
1907 KP13_02400 Siroheme synthase 1 cysG1 AlphaFold DB model + ColabFold model –
GO:0004851Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+. GO:0051266Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
No map 0.734 0.752 No Hit 0.0% —
1908 KP13_00371 Maltose transport system permease protein malF malF AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990060Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. +25 total
No map 0.734 0.51 No Hit 0.0% —
1909 KP13_04861 Isocitrate dehydrogenase [NADP] icd AlphaFold DB model + ColabFold model
1.1.1.42
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0000287Binding to a magnesium (Mg) ion. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +36 total
No map 0.733 0.449 Hit 40.7% 4.43e-08
1910 KP13_03896 putative tartrate dehydrogenase/decarboxylase AlphaFold DB model + ColabFold model
1.1.1.83
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0000287Binding to a magnesium (Mg) ion. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +14 total
No map 0.733 0.375 Hit 41.2% 1.30e-09
1911 KP13_03084 putative transmembrane protein ColabFold model – – No map N/A 0.733 No Hit 0.0% —
1912 KP13_03013 putative Acriflavin resistance protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.733 0.45 No Hit 0.0% —
1913 KP13_01462 Protein methyltransferase hemK hemK AlphaFold DB model + ColabFold model
2.1.1.297
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003676Binding to a nucleic acid. GO:0006479The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. +36 total
No map 0.733 0.929 Hit 29.9% 2.53e-17
1914 KP13_00231 Valine--pyruvate aminotransferase avtA AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
No map 0.733 0.525 Hit 26.0% 1.46e-08
1915 KP13_04834 Outer membrane protein S1 ompS1 AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034220A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. +25 total
No map 0.732 0.99 No Hit 0.0% —
1916 KP13_04728 putative glucose-6-phosphate 1-epimerase AlphaFold DB model + ColabFold model
5.1.3.15
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +36 total
No map 0.732 0.171 No Hit 0.0% —
1917 KP13_00360 Lysine-sensitive aspartokinase 3 lysC AlphaFold DB model + ColabFold model
2.7.2.4
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0004072Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. +47 total
No map 0.732 0.596 No Hit 0.0% —
1918 KP13_00205 putative glycosyltransferase, family 2 AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.732 0.468 No Hit 0.0% —
1919 KP13_04183 Hedgehog signaling domain-containing protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
No map 0.731 0.279 No Hit 0.0% —
1920 KP13_03294 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.731 No Hit 0.0% —
1921 KP13_02250 putative acetyl-CoA acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. +14 total
No map 0.731 0.952 Hit 49.3% 2.06e-12
1922 KP13_32242 Type II secretion system protein E AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.730 0.487 No Hit 0.0% —
1923 KP13_03709 hypothetical protein Experimental + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map N/A 0.73 No Hit 0.0% —
1924 KP13_02409 cytotoxic necrotizing factor-like protein AlphaFold DB model + ColabFold model –
GO:0005507Binding to a copper (Cu) ion. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No map 0.730 0.466 Hit 37.5% 2.99e-09
1925 KP13_02173 Xaa-Pro aminopeptidase pepP AlphaFold DB model + ColabFold model
3.4.11.9
GO:0030145Binding to a manganese ion (Mn). GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.730 0.191 Hit 39.3% 9.95e-24
Page of 234 · 5842 total proteins