Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1901 KP13_03401 Ferrienterobactin-binding periplasmic protein fepB AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.71 No Hit 0.0% —
1902 KP13_02158 Transketolase 1 tktA AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004802Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.
0.71 Hit 35.9% 1.75e-16
1903 KP13_01653 nucleic acid binding domain-containing protein AlphaFold + ColabFold – – 0.71 No Hit 0.0% —
1904 KP13_00586 hypothetical protein AlphaFold + ColabFold –
GO:0030151Binding to a molybdenum ion (Mo). GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.71 No Hit 0.0% —
1905 KP13_00354 Methionine synthase metH AlphaFold + ColabFold
2.1.1.13
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0008270Binding to a zinc ion (Zn). GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +811 total
0.71 Hit 57.4% 5.62e-29
1906 KP13_31905 Putative aliphatic sulfonates transport permease protein ssuC ssuC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.709 No Hit 0.0% —
1907 KP13_31494 Bifunctional purine biosynthesis protein purH purH AlphaFold + ColabFold –
GO:0004643Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. GO:0003937Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.709 Hit 60.0% 1.95e-22
1908 KP13_04656 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.709 No Hit 0.0% —
1909 KP13_02833 putative transmembrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.709 No Hit 0.0% —
1910 KP13_01720 Threonine efflux protein rhtC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.709 No Hit 0.0% —
1911 KP13_00600 Raffinose permease rafB AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005351Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). +14 total
0.709 No Hit 0.0% —
1912 KP13_00327 putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD arnD AlphaFold + ColabFold
3.5.1.n3
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. +58 total
0.709 No Hit 0.0% —
1913 KP13_00056 2-oxo-3-deoxygalactonate kinase dgoK Experimental + ColabFold –
GO:0008671Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+. GO:0034194The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.
0.709 No Hit 0.0% —
1914 KP13_31604 Inner membrane transport protein AlphaFold + ColabFold –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.708 No Hit 0.0% —
1915 KP13_05430 hypothetical protein AlphaFold + ColabFold – – 0.708 No Hit 0.0% —
1916 KP13_03173 Hydroxyethylthiazole kinase thiM Experimental + ColabFold –
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0000287Binding to a magnesium (Mg) ion. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.708 No Hit 0.0% —
1917 KP13_03089 putative transmembrane protein AlphaFold + ColabFold – – 0.708 No Hit 0.0% —
1918 KP13_32392 hypothetical protein ColabFold – – 0.707 No Hit 0.0% —
1919 KP13_32234 DNA repair protein UmuC AlphaFold + ColabFold –
GO:0003684Binding to damaged DNA. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
0.707 No Hit 0.0% —
1920 KP13_04156 hypothetical protein AlphaFold + ColabFold – – 0.707 No Hit 0.0% —
1921 KP13_03942 Polymerase/histidinol phosphatase domain-containing protein AlphaFold + ColabFold – – 0.707 No Hit 0.0% —
1922 KP13_01800 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase lpxD AlphaFold + ColabFold
2.3.1.191
GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0016410Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +36 total
0.707 No Hit 0.0% —
1923 KP13_00841 hypothetical protein AlphaFold + ColabFold – – 0.707 No Hit 0.0% —
1924 KP13_00808 Sigma-E factor regulatory protein rseB rseB AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0045152Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator. GO:0032885Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.
0.707 No Hit 0.0% —
1925 KP13_00764 50S ribosomal protein L6 rplF AlphaFold + ColabFold –
GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +36 total
0.707 No Hit 0.0% —
Page of 234 · 5842 total proteins