Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
176 KP13_03514 hypothetical protein AlphaFold + ColabFold – – 0.983 No Hit 0.0% —
177 KP13_02563 6-phospho-beta-glucosidase gmuD AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.983 Hit 32.8% 4.51e-28
178 KP13_00987 NADH-quinone oxidoreductase subunit H nuoH AlphaFold + ColabFold
7.1.1.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003954Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. +36 total
0.983 Hit 41.5% 2.51e-61
179 KP13_00476 hypothetical protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.983 No Hit 0.0% —
180 KP13_32072 resolvase resD AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.982 No Hit 0.0% —
181 KP13_31571 Inner membrane transporter AlphaFold + ColabFold –
GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. +58 total
0.982 Hit 31.7% 2.17e-17
182 KP13_04946 Glucans biosynthesis glucosyltransferase H mdoH AlphaFold + ColabFold
2.4.1.-
GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009250The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.
0.982 No Hit 0.0% —
183 KP13_04069 Zinc-type alcohol dehydrogenase-like protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn).
0.982 Hit 31.7% 1.75e-07
184 KP13_03488 putative oxidoreductase protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.982 No Hit 0.0% —
185 KP13_00598 putative alcohol dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. GO:0004022Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
0.982 Hit 26.4% 1.78e-28
186 KP13_00366 putative branched-chain amino acid transport protein AlphaFold + ColabFold – – 0.982 No Hit 0.0% —
187 KP13_26403 Phosphatidylglycerophosphatase B pgpB AlphaFold + ColabFold
3.6.1.27
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050380Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate.
0.981 No Hit 0.0% —
188 KP13_04562 putative oxidoreductase AlphaFold + ColabFold
1.2.1.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.981 Hit 36.4% 2.97e-12
189 KP13_03859 Dihydroorotate dehydrogenase pyrD AlphaFold + ColabFold
1.3.5.2
GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +69 total
0.981 Hit 47.1% 1.05e-27
190 KP13_03263 tetratricopeptide-like helical domain-containing protein AlphaFold + ColabFold –
GO:0070206The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. GO:0005515Binding to a protein. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +25 total
0.981 No Hit 0.0% —
191 KP13_03034 Transcriptional regulatory protein basR basR Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
0.981 No Hit 0.0% —
192 KP13_01878 Dihydrolipoyl dehydrogenase lpdA AlphaFold + ColabFold
1.8.1.4
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016668Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. +47 total
0.981 Hit 52.8% 7.04e-16
193 KP13_00983 NADH-quinone oxidoreductase subunit L nuoL AlphaFold + ColabFold –
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
0.981 Hit 39.3% 2.43e-76
194 KP13_00540 Protein aidB aidB AlphaFold + ColabFold –
GO:0003995Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
0.981 Hit 29.7% 6.12e-14
195 KP13_03913 Putative pyrimidine permease rutG rutG AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0006864The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
0.98 Hit 32.4% 4.20e-11
196 KP13_03081 Thioredoxin-like fold-containing protein AlphaFold + ColabFold – – 0.98 No Hit 0.0% —
197 KP13_01754 2-hydroxyglutaryl-CoA dehydratase AlphaFold + ColabFold – – 0.98 No Hit 0.0% —
198 KP13_01748 YhgA-like domain-containing protein AlphaFold + ColabFold –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
0.98 No Hit 0.0% —
199 KP13_00355 Na/Pi co-transporter II-related protein AlphaFold + ColabFold –
GO:0005436Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0044341The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.
0.98 No Hit 0.0% —
200 KP13_04709 Respiratory nitrate reductase 1 gamma chain narI AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0008940Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +69 total
0.979 No Hit 0.0% —
Page of 234 · 5842 total proteins