Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1976 KP13_04689 Cardiolipin synthase cls AlphaFold DB model + ColabFold model
2.7.8.-
GO:0008808Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. GO:0032049The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). +25 total
No map 0.718 0.412 No Hit 0.0% —
1977 KP13_03873 Cell division inhibitor sulA sulA AlphaFold DB model + ColabFold model –
GO:0009432An error-prone process for repairing damaged microbial DNA. GO:0051782Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. GO:0000917The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. +14 total
No map 0.718 0.566 No Hit 0.0% —
1978 KP13_02924 Na(+)-translocating NADH-quinone reductase subunit B nqrB AlphaFold DB model + ColabFold model
7.2.1.1
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022904A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. +47 total
No map 0.717 0.939 No Hit 0.0% —
1979 KP13_02743 tRNA (guanine-N(7)-)-methyltransferase trmB AlphaFold DB model + ColabFold model
2.1.1.33
GO:0008176Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. GO:0043527A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.
No map 0.717 0.757 Hit 27.1% 6.87e-06
1980 KP13_00972 Nucleoside triphosphatase nudI nudI Experimental + ColabFold model
3.6.1.9 3.6.1.12 3.6.1.- +14 total
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0047840Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate. +25 total
No map 0.717 0.472 No Hit 0.0% —
1981 KP13_00920 Bacteriophage T7 tail fiber protein ColabFold model – – No map 0.717 0.954 No Hit 0.0% —
1982 KP13_00915 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.717 No Hit 0.0% —
1983 KP13_00713 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.717 No Hit 0.0% —
1984 KP13_31900 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase msbB AlphaFold DB model + ColabFold model
2.3.1.243
GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
No map 0.716 0.86 No Hit 0.0% —
1985 KP13_03817 DNA replication initiation factor hda AlphaFold DB model + ColabFold model –
GO:0032297Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.
No map 0.716 0.487 No Hit 0.0% —
1986 KP13_03081 Thioredoxin-like fold-containing protein AlphaFold DB model + ColabFold model – – No map 0.716 0.98 No Hit 0.0% —
1987 KP13_02774 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.716 No Hit 0.0% —
1988 KP13_02481 2-dehydro-3-deoxy-6-phosphogalactonate aldolase AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
No map 0.716 0.577 No Hit 0.0% —
1989 KP13_00534 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.716 No Hit 0.0% —
1990 KP13_31509 L-2,4-diaminobutyrate decarboxylase ddc AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016830Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. +36 total
No map 0.715 0.636 Hit 49.0% 1.76e-23
1991 KP13_00196 putative protein in waa region AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.715 0.556 No Hit 0.0% —
1992 KP13_02097 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.714 0.336 No Hit 0.0% —
1993 KP13_32388 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.713 No Hit 0.0% —
1994 KP13_05628 Site-specific DNA-methyltransferase (cytosine-N4-specific) AlphaFold DB model + ColabFold model
2.1.1.-
GO:0090124OBSOLETE. The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule. GO:0006306OBSOLETE. The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. GO:0008170Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. +47 total
No map 0.713 0.434 No Hit 0.0% —
1995 KP13_03179 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
No map 0.713 0.731 No Hit 0.0% —
1996 KP13_02575 Formate hydrogenlyase subunit 4 hycD AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.713 0.998 No Hit 0.0% —
1997 KP13_32184 oligoribonuclease AlphaFold DB model + ColabFold model
3.1.-.-
GO:0003676Binding to a nucleic acid. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.712 0.317 Hit 58.7% 3.85e-12
1998 KP13_31567 Glucitol/sorbitol permease IIC component srlA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
No map 0.712 0.766 No Hit 0.0% —
1999 KP13_03575 Lipid A biosynthesis lauroyl acyltransferase htrB AlphaFold DB model + ColabFold model
2.3.1.241
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. +47 total
No map 0.712 0.316 No Hit 0.0% —
2000 KP13_03091 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.712 0.401 No Hit 0.0% —
Page of 234 · 5842 total proteins