Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3051 PA0675 ECF sigma factor VreI vreI, PA0675 AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. +36 total
No map 0.712 No Hit N/A —
3052 PA0552 phosphoglycerate kinase pgk, PA0552 AlphaFold DB model
2.7.2.3
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043531Binding to ADP, adenosine 5'-diphosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
No map 0.712 Hit 39.7% 3.21e-86
3053 PA0398 hypothetical protein PA0398 AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.712 No Hit N/A —
3054 PA0295 polyamine binding protein PA0295 AlphaFold DB model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0019810Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. GO:0019809Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. +47 total
No map 0.712 No Hit N/A —
3055 PA4343 major facilitator superfamily transporter PA4343 AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
No map 0.711 No Hit N/A —
3056 PA4009 hypothetical protein PA4009 AlphaFold DB model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.711 No Hit N/A —
3057 PA3860 acyl-CoA synthetase PA3860 AlphaFold DB model –
GO:0016878Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0016405Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.
No map 0.711 Hit 35.4% 6.62e-15
3058 PA3222 hypothetical protein PA3222 AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.711 No Hit N/A —
3059 PA2085 ring-hydroxylating dioxygenase small subunit PA2085 AlphaFold DB model –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0019380The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid. GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
No map 0.711 No Hit N/A —
3060 PA2068 major facilitator superfamily transporter PA2068 AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0030395Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. GO:0015528Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in).
No map 0.711 No Hit N/A —
3061 PA1330 short-chain dehydrogenase PA1330 AlphaFold DB model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.711 Hit 38.5% 1.75e-18
3062 PA5393 hypothetical protein PA5393 AlphaFold DB model –
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
No map 0.71 Hit 26.8% 2.37e-07
3063 PA5213 glycine dehydrogenase gcvP1 ColabFold model –
GO:0006546The chemical reactions and pathways resulting in the breakdown of glycine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006544The chemical reactions and pathways involving glycine, aminoethanoic acid. +14 total
No map 0.71 Hit 65.5% 2.21e-21
3064 PA4870 hypothetical protein PA4870 AlphaFold DB model –
GO:0008270Binding to a zinc ion (Zn). GO:1900378Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
No map 0.71 No Hit N/A —
3065 PA4670 ribose-phosphate pyrophosphokinase prs, PA4670 AlphaFold DB model
2.7.6.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0002189A protein complex having ribose phosphate diphosphokinase activity. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +811 total
No map 0.71 Hit 56.5% 2.71e-19
3066 PA4640 malate:quinone oxidoreductase mqoB, PA4640, mqo2 AlphaFold DB model
1.1.5.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008924Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol. Vitamin K (menaquinone) and several other quinones can act as acceptors. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
No map 0.71 No Hit N/A —
3067 PA4569 octaprenyl-diphosphate synthase PA4569, ispB AlphaFold DB model
2.5.1.90
GO:0106350Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate. GO:0046872Binding to a metal ion. GO:0004659Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). +14 total
No map 0.71 Hit 29.8% 2.94e-09
3068 PA4369 hypothetical protein PA4369 AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.71 No Hit N/A —
3069 PA3551 bifunctional mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase algA, PA3551, pmi AlphaFold DB model –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0004475Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. GO:0004476Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. +69 total
No map 0.71 No Hit N/A —
3070 PA3366 acylamide amidohydrolase PA3366, amiE Experimental + AlphaFold DB model
3.5.1.4
GO:0004040Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+. GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0043605OBSOLETE. The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. +25 total
No map 0.71 Hit 26.8% 5.94e-10
3071 PA3330 short-chain dehydrogenase PA3330 AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.71 Hit 47.2% 2.02e-06
3072 PA2724 hypothetical protein PA2724 AlphaFold DB model – – No map 0.71 No Hit N/A —
3073 PA1500 2-hydroxy-3-oxopropionate reductase PA1500 AlphaFold DB model –
GO:0008679Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +25 total
No map 0.71 Hit 35.6% 1.05e-24
3074 PA1134 hypothetical protein PA1134 AlphaFold DB model –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
No map 0.71 No Hit N/A —
3075 PA0844 hemolytic phospholipase C PA0844, plcH AlphaFold DB model
3.1.4.3
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0016298Catalysis of the hydrolysis of a lipid. GO:0034480Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine. +710 total
No map 0.71 No Hit N/A —
Page of 223 · 5572 total proteins