Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3076 PA0049 hypothetical protein PA0049 AlphaFold – – No map 0.71 No Hit N/A —
3077 PA5513 hypothetical protein PA5513, poxA AlphaFold – – No map 0.709 No Hit N/A —
3078 PA5380 protein GbdR gbdR, PA5380 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +710 total
No map 0.709 No Hit N/A —
3079 PA5366 phosphate ABC transporter ATP-binding protein PA5366, pstB AlphaFold
7.3.2.1
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +69 total
No map 0.709 Hit 38.3% 9.86e-08
3080 PA4965 hypothetical protein PA4965 AlphaFold – – No map 0.709 No Hit N/A —
3081 PA4888 acyl-CoA desaturase desB, PA4888 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016717Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. +14 total
No map 0.709 Hit 29.9% 6.48e-06
3082 PA4750 dihydropteroate synthase folP, PA4750 AlphaFold
2.5.1.15
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004156Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. GO:0046872Binding to a metal ion. +58 total
No map 0.709 No Hit N/A —
3083 PA4127 2-oxo-hepta-3-ene-1,7-dioic acid hydratase PA4127, hpcG AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0018817Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate. GO:0008684Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O. +25 total
No map 0.709 No Hit N/A —
3084 PA3947 DNA-binding response regulator RocR rocR, sadR, PA3947 Experimental + AlphaFold
3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:0046872Binding to a metal ion. +25 total
No map 0.709 No Hit N/A —
3085 PA3484 hypothetical protein PA3484, tse3 Experimental + AlphaFold
3.2.1.17
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033644Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. GO:0003796Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. +14 total
No map 0.709 No Hit N/A —
3086 PA3454 acyl-CoA thiolase PA3454 Experimental + AlphaFold
2.3.1.16
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033812Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. +47 total
No map 0.709 Hit 45.8% 5.02e-103
3087 PA3226 hydrolase PA3226 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.709 Hit 26.6% 1.93e-06
3088 PA2886 hypothetical protein atuA, PA2886 AlphaFold –
GO:0046247The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units.
No map 0.709 No Hit N/A —
3089 PA2838 transcriptional regulator PA2838 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.709 No Hit N/A —
3090 PA2431 hypothetical protein PA2431 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.709 No Hit N/A —
3091 PA2336 hypothetical protein PA2336 AlphaFold –
GO:0004062Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
No map 0.709 No Hit N/A —
3092 PA2317 oxidoreductase PA2317 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.709 No Hit N/A —
3093 PA2230 hypothetical protein PA2230 AlphaFold – – No map 0.709 No Hit N/A —
3094 PA1651 transporter PA1651 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042925Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
No map 0.709 No Hit N/A —
3095 PA1267 hypothetical protein PA1267 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0019470The chemical reactions and pathways resulting in the breakdown of trans-4-hydroxy-L-proline.
No map 0.709 Hit 22.3% 4.92e-10
3096 PA0283 sulfate-binding protein sbp, PA0283 AlphaFold –
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0140104Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. +47 total
No map 0.709 No Hit N/A —
3097 PA0105 cytochrome C oxidase subunit II PA0105, coxB AlphaFold
7.1.1.9
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0098803Any protein complex that is part of a respiratory chain. GO:0005507Binding to a copper (Cu) ion. +710 total
No map 0.709 Hit 37.3% 5.29e-38
3098 PA2769 hypothetical protein PA2769 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.708 Hit 43.0% 3.83e-25
3099 PA2714 molybdopterin oxidoreductase PA2714 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1990204Any protein complex that possesses oxidoreductase activity. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +47 total
No map 0.708 No Hit N/A —
3100 PA1913 hypothetical protein PA1913 AlphaFold – – No map 0.708 No Hit N/A —
Page of 223 · 5572 total proteins