Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

Search, filter, and prioritize proteins.

Export view
5572 / 5572 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3101 PA1740 hypothetical protein PA1740 AlphaFold – – No map 0.708 No Hit N/A —
3102 PA1488 hypothetical protein PA1488 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.708 No Hit N/A —
3103 PA1336 two-component sensor PA1336 AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +36 total
No map 0.708 No Hit N/A —
3104 PA5410 protein GbcA gbcA, PA5410 AlphaFold
1.14.13.251
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005506Binding to an iron (Fe) ion. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. +25 total
No map 0.707 No Hit N/A —
3105 PA5184 chorismate mutase aroQ, PA5184 Experimental + AlphaFold
5.4.99.5
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004106Catalysis of the reaction: chorismate = prephenate. GO:0042803Binding to an identical protein to form a homodimer. +36 total
No map 0.707 No Hit N/A —
3106 PA3840 SAM-dependent methyltransferase rlmF, PA3840 AlphaFold
2.1.1.181
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0052907Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA. GO:0070475The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. +36 total
No map 0.707 Hit 35.9% 1.37e-10
3107 PA3736 homoserine dehydrogenase PA3736, hom AlphaFold
1.1.1.3
GO:0004412Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. GO:0046872Binding to a metal ion. GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. +58 total
No map 0.707 No Hit N/A —
3108 PA3721 transcriptional regulator PA3721, nalC Experimental + AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +36 total
No map 0.707 No Hit N/A —
3109 PA3227 peptidyl-prolyl cis-trans isomerase A cypH, PA3227, ppiA AlphaFold
5.2.1.8
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +14 total
No map 0.707 Hit 46.2% 1.13e-10
3110 PA2878 hypothetical protein PA2878 AlphaFold –
GO:0005515Binding to a protein.
No map 0.707 No Hit N/A —
3111 PA2830 protease HtpX PA2830, htpX AlphaFold
3.4.24.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0008270Binding to a zinc ion (Zn). +14 total
No map 0.707 No Hit N/A —
3112 PA2003 3-hydroxybutyrate dehydrogenase PA2003, bdhA AlphaFold –
GO:0003858Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH. GO:0016628Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0032787The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). +14 total
No map 0.707 Hit 40.3% 4.60e-07
3113 PA1866 hypothetical protein PA1866 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +69 total
No map 0.707 Hit 28.5% 8.03e-09
3114 PA1630 transcriptional regulator PA1630 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.707 No Hit N/A —
3115 PA1102 flagellar motor switch protein FliG fliG, PA1102 AlphaFold –
GO:0009425One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003774Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). +36 total
No map 0.707 No Hit N/A —
3116 PA0441 D-hydantoinase/dihydropyrimidinase dht, PA0441 Experimental + AlphaFold
3.5.2.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004157Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. GO:0016812Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. +69 total
No map 0.707 Hit 51.2% 1.30e-170
3117 PA0267 hypothetical protein PA0267 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +36 total
No map 0.707 No Hit N/A —
3118 PA4663 molybdopterin biosynthesis protein MoeB moeB, PA4663 AlphaFold
2.7.7.80
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
No map 0.706 Hit 47.4% 5.86e-56
3119 PA3735 threonine synthase PA3735, thrC AlphaFold
4.2.3.1
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0004795Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate. GO:0009088The chemical reactions and pathways resulting in the formation of L-threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. +14 total
No map 0.706 Hit 36.5% 4.31e-19
3120 PA3387 3-oxoacyl-ACP reductase PA3387, rhlG Experimental + AlphaFold
1.1.1.100
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004316Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. GO:0008709Catalysis of the reaction: cholate + NAD+ = -3alpha,12-alpha-dihydroxy-7-oxo--5beta-cholanate + H+ + NADH.
No map 0.706 Hit 35.8% 3.04e-09
3121 PA3151 imidazole glycerol phosphate synthase subunit HisF hisF2, PA3151 AlphaFold
4.3.2.10
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. GO:0016833Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. +25 total
No map 0.706 No Hit N/A —
3122 PA3119 hypothetical protein ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
No map 0.706 Hit 40.5% 7.90e-07
3123 PA3043 deoxyguanosinetriphosphate triphosphohydrolase dgt2, PA3043 AlphaFold –
GO:0008832Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate. GO:0006203The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. GO:0016793Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group.
No map 0.706 No Hit N/A —
3124 PA2176 hypothetical protein PA2176 AlphaFold – – No map 0.706 No Hit N/A —
3125 PA2074 hypothetical protein PA2074 AlphaFold –
GO:0050126Catalysis of the reaction: N-carbamoylputrescine + H2O + 2 H+ = CO2 + NH4 + putrescine. GO:0033388The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
No map 0.706 Hit 32.3% 1.45e-21
Page of 223 · 5572 total proteins