Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3876 PA2703 hypothetical protein tsi2, PA2703 Experimental + AlphaFold – – 0.622 No Hit N/A —
3877 PA1758 para-aminobenzoate synthase component I PA1758, pabB AlphaFold
2.6.1.85
GO:0046820Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. +14 total
0.622 No Hit N/A —
3878 PA1395 hypothetical protein PA1395 AlphaFold – – 0.622 No Hit N/A —
3879 PA0956 proline--tRNA ligase PA0956, proS Experimental + AlphaFold
6.1.1.15
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
0.622 Hit 47.8% 5.10e-67
3880 PA0478 N-acetyltransferase PA0478 Experimental + AlphaFold –
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.622 Hit 37.1% 2.20e-30
3881 PA0134 guanine deaminase PA0134 AlphaFold
3.5.4.3
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008892Catalysis of the reaction: guanine + H2O + H+ = xanthine + NH4+. GO:0008270Binding to a zinc ion (Zn). +47 total
0.622 Hit 32.4% 3.95e-56
3882 PA5329 hypothetical protein PA5329 AlphaFold –
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.621 No Hit N/A —
3883 PA3956 hypothetical protein PA3956 AlphaFold – – 0.621 No Hit N/A —
3884 PA3212 ABC transporter ATP-binding protein PA3212 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.621 Hit 34.7% 6.75e-21
3885 PA2289 hypothetical protein PA2289 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0044718The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.
0.621 No Hit N/A —
3886 PA1827 short-chain dehydrogenase PA1827 AlphaFold –
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.621 Hit 42.7% 2.03e-10
3887 PA1555 cytochrome C oxidase cbb3-type subunit CcoP PA1555, ccoP2 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004129Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +47 total
0.621 No Hit N/A —
3888 PA5334 ribonuclease PH rph, PA5334 Experimental + AlphaFold
2.7.7.56
GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0000049Binding to a transfer RNA. +47 total
0.62 Hit 27.2% 1.40e-08
3889 PA5177 hydrolase PA5177 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion. GO:0008967Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. +14 total
0.62 No Hit N/A —
3890 PA3168 DNA gyrase subunit A gyrA, PA3168 AlphaFold
5.6.2.2
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009330Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity. +811 total
0.62 Hit 25.4% 2.93e-14
3891 PA1469 hypothetical protein PA1469 AlphaFold –
GO:0005507Binding to a copper (Cu) ion. GO:0017061Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.
0.62 Hit 30.1% 8.23e-07
3892 PA0550 hypothetical protein PA0550 AlphaFold –
GO:0008903Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. GO:0046487The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
0.62 Hit 49.8% 5.46e-66
3893 PA5331 orotate phosphoribosyltransferase PA5331, pyrE AlphaFold
2.4.2.10
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000287Binding to a magnesium (Mg) ion. GO:0004588Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. +47 total
0.619 Hit 31.9% 3.19e-08
3894 PA4672 peptidyl-tRNA hydrolase PA4672, pth Experimental + AlphaFold
3.1.1.29
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004045Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+. GO:0000049Binding to a transfer RNA. +25 total
0.619 Hit 40.1% 1.02e-25
3895 PA4517 hypothetical protein PA4517 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016776Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). GO:0009244The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. +36 total
0.619 No Hit N/A —
3896 PA4515 hydroxylase PA4515, piuC Experimental + AlphaFold
1.14.11.-
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0005506Binding to an iron (Fe) ion. GO:0031418Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. +47 total
0.619 No Hit N/A —
3897 PA4378 hypothetical protein PA4378, inaA AlphaFold – – 0.619 No Hit N/A —
3898 PA3120 isopropylmalate isomerase small subunit PA3120, leuD AlphaFold
4.2.1.33
GO:0009316A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. GO:0003861Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid.
0.619 No Hit N/A —
3899 PA2323 glyceraldehyde-3-phosphate dehydrogenase PA2323 AlphaFold –
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.619 Hit 47.7% 1.04e-06
3900 PA2187 hypothetical protein PA2187 AlphaFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.619 No Hit N/A —
Page of 223 · 5572 total proteins