Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3926 PA4675 TonB-dependent receptor PA4675 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0038023Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. +36 total
0.615 No Hit N/A —
3927 PA4299 type II secretion system protein TadD tadD ColabFold –
GO:0005515Binding to a protein.
0.615 No Hit N/A —
3928 PA4044 1-deoxy-D-xylulose-5-phosphate synthase PA4044, dxs AlphaFold
2.2.1.7
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008661Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2. GO:0000287Binding to a magnesium (Mg) ion. +58 total
0.615 Hit 25.0% 3.60e-24
3929 PA3259 hypothetical protein PA3259 AlphaFold –
GO:0005515Binding to a protein.
0.615 No Hit N/A —
3930 PA2555 AMP-binding protein PA2555 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003987Catalysis of the reaction: acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.615 Hit 42.6% 2.04e-06
3931 PA1844 hypothetical protein tse1, PA1844 Experimental + AlphaFold
3.4.19.11
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033644Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. GO:0004040Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+.
0.615 No Hit N/A —
3932 PA0117 short-chain dehydrogenase PA0117 AlphaFold – – 0.615 Hit 28.1% 5.91e-17
3933 PA4391 hypothetical protein PA4391 AlphaFold – – 0.614 No Hit N/A —
3934 PA3383 phosphonate ABC transporter substrate-binding protein PA3383 Experimental + AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). +14 total
0.614 No Hit N/A —
3935 PA2529 hypothetical protein PA2529 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.614 No Hit N/A —
3936 PA2332 transcriptional regulator PA2332 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.614 No Hit N/A —
3937 PA0776 hypothetical protein PA0776 AlphaFold – – 0.614 No Hit N/A —
3938 PA4526 type 4 fimbrial biogenesis protein PilB pilB, PA4526 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +710 total
0.613 No Hit N/A —
3939 PA4400 hypothetical protein PA4400 AlphaFold
3.6.1.55
GO:0035539Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. GO:0008413Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. GO:0044715Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate. +69 total
0.613 No Hit N/A —
3940 PA3932 transcriptional regulator PA3932 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +58 total
0.613 No Hit N/A —
3941 PA2620 ATP-binding protease component ClpA clpA, PA2620 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +47 total
0.613 Hit 41.1% 1.81e-39
3942 PA2503 hypothetical protein PA2503 AlphaFold – – 0.613 No Hit N/A —
3943 PA1116 hypothetical protein PA1116 AlphaFold –
GO:0003676Binding to a nucleic acid.
0.613 No Hit N/A —
3944 PA0781 hypothetical protein PA0781 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0044718The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.
0.613 No Hit N/A —
3945 PA0178 two-component sensor PA0178 AlphaFold
2.7.13.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +710 total
0.613 No Hit N/A —
3946 PA0087 hypothetical protein tssE1, PA0087 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.613 No Hit N/A —
3947 PA5302 alanine racemase dadX, PA5302 Experimental + AlphaFold
5.1.1.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +36 total
0.612 No Hit N/A —
3948 PA5287 ammonium transporter PA5287, amtB AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008519Enables the energy-independent facilitated diffusion of ammonium through a transmembrane aqueous pore or channel. GO:0072488The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. +14 total
0.612 No Hit N/A —
3949 PA2273 redox-sensitive transcriptional activator SoxR PA2273, soxR AlphaFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.612 No Hit N/A —
3950 PA2233 biofilm formation protein PslC pslC, PA2233 AlphaFold
2.4.1.377
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. +14 total
0.612 No Hit N/A —
Page of 223 · 5572 total proteins