Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3826 PA3475 cyclohexadienyl dehydratase pheC, PA3475 Experimental + AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0047769Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2. GO:0004664Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. +25 total
0.629 No Hit N/A —
3827 PA3266 major cold shock protein CspA capB ColabFold –
GO:0003676Binding to a nucleic acid.
0.629 Hit 41.9% 4.00e-07
3828 PA3075 hypothetical protein PA3075 AlphaFold – – 0.629 No Hit N/A —
3829 PA2974 hydrolase PA2974 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion. GO:0008967Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. +14 total
0.629 No Hit N/A —
3830 PA1564 sulfurtransferase TusA PA1564, tusA AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
0.629 No Hit N/A —
3831 PA0359 hypothetical protein PA0359 AlphaFold – – 0.629 No Hit N/A —
3832 PA1279 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT, cobU, PA1279 AlphaFold
2.4.2.21
GO:0008939Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.628 No Hit N/A —
3833 PA1218 hypothetical protein PA1218 AlphaFold –
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0005506Binding to an iron (Fe) ion.
0.628 No Hit N/A —
3834 PA1178 PhoP/Q and low Mg2+ inducible outer membrane protein H1 PA1178, oprH AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0001530Binding to a lipopolysaccharide.
0.628 No Hit N/A —
3835 PA1148 exotoxin A toxA ColabFold –
GO:0047286Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide.
0.628 No Hit N/A —
3836 PA1080 flagellar hook protein FlgE flgE, PA1080 AlphaFold –
GO:0009288A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0009425One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0009424The portion of the bacterial-type flagellum that connects the filament to the basal body. +25 total
0.628 No Hit N/A —
3837 PA0801 hypothetical protein PA0801 AlphaFold – – 0.628 No Hit N/A —
3838 PA4556 type 4 fimbrial biogenesis protein PilE fimA, PA4556, pilE Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009297The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0043683The assembly from its constituent parts of a type IV pilus. +14 total
0.627 No Hit N/A —
3839 PA3173 short-chain dehydrogenase PA3173 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.627 Hit 32.8% 5.84e-10
3840 PA2929 hypothetical protein PA2929 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015171Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.627 No Hit N/A —
3841 PA0981 hypothetical protein PA0981 AlphaFold – – 0.627 No Hit N/A —
3842 PA4723 suppressor protein DksA dksA, PA4723, dksA_1 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0070063Binding to an RNA polymerase molecule or complex. GO:0008270Binding to a zinc ion (Zn). +58 total
0.626 No Hit N/A —
3843 PA4424 hypothetical protein PA4424 AlphaFold –
GO:0003676Binding to a nucleic acid.
0.626 No Hit N/A —
3844 PA4043 geranyltranstransferase PA4043, ispA Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. GO:0004659Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). +36 total
0.626 Hit 28.9% 5.72e-13
3845 PA3804 hypothetical protein PA3804 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.626 No Hit N/A —
3846 PA3746 signal recognition particle protein Ffh PA3746, ffh AlphaFold
3.6.5.4
GO:0048500A complex of protein and RNA which facilitates translocation of proteins across membranes. GO:0008312Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). GO:0005525Binding to GTP, guanosine triphosphate. +36 total
0.626 Hit 34.7% 1.49e-56
3847 PA3172 phosphoglycolate phosphatase mupP, PA3172 AlphaFold
3.1.3.105
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion. GO:0008967Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. +69 total
0.626 No Hit N/A —
3848 PA1172 cytochrome C protein NapC PA1172, napC AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +47 total
0.626 No Hit N/A —
3849 PA0919 hypothetical protein PA0919 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0055091Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
0.626 No Hit N/A —
3850 PA0293 N-carbamoylputrescine amidohydrolase aguB, PA0293 AlphaFold –
GO:0050126Catalysis of the reaction: N-carbamoylputrescine + H2O + 2 H+ = CO2 + NH4 + putrescine. GO:0033388The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine. GO:0006596The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. +14 total
0.626 Hit 32.7% 4.96e-15
Page of 223 · 5572 total proteins