Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3901 PA1695 translocation protein in type III secretion PA1695, pscP Experimental + AlphaFold –
GO:0030254The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
0.619 No Hit N/A —
3902 PA1045 ATP-dependent DNA helicase DinG PA1045, dinG AlphaFold
5.6.2.3
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0043139Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +1114 total
0.619 No Hit N/A —
3903 PA5407 hypothetical protein PA5407 AlphaFold – – 0.618 No Hit N/A —
3904 PA3765 hypothetical protein PA3765 AlphaFold – – 0.618 No Hit N/A —
3905 PA3274 hypothetical protein PA3274 AlphaFold – – 0.618 No Hit N/A —
3906 PA2070 hypothetical protein PA2070 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.618 No Hit N/A —
3907 PA5545 hypothetical protein PA5545 AlphaFold – – 0.617 No Hit N/A —
3908 PA4111 hypothetical protein PA4111 AlphaFold – – 0.617 No Hit N/A —
3909 PA3705 hypothetical protein PA3705, wspD AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
0.617 No Hit N/A —
3910 PA3380 hypothetical protein PA3380 AlphaFold –
GO:0019634The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2).
0.617 No Hit N/A —
3911 PA2977 UDP-N-acetylenolpyruvoylglucosamine reductase murB, PA2977 Experimental + AlphaFold
1.3.1.98
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +58 total
0.617 No Hit N/A —
3912 PA2965 3-oxoacyl-ACP synthase PA2965, fabF1 Experimental + AlphaFold
2.3.1.179
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0046872Binding to a metal ion. +36 total
0.617 Hit 47.3% 3.52e-120
3913 PA2414 L-sorbosone dehydrogenase PA2414 AlphaFold – – 0.617 No Hit N/A —
3914 PA1549 cation-transporting P-type ATPase PA1549 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +912 total
0.617 Hit 39.4% 9.22e-07
3915 PA5547 hypothetical protein PA5547 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0036424Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.616 No Hit N/A —
3916 PA4438 hypothetical protein PA4438, zapE AlphaFold –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
0.616 Hit 55.2% 1.35e-14
3917 PA3141 nucleotide sugar epimerase/dehydratase WbpM PA3141, wbpM AlphaFold –
GO:0006045The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. GO:0009243The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.
0.616 Hit 22.7% 4.62e-07
3918 PA2978 phosphotyrosine protein phosphatase ptpA, PA2978 AlphaFold
3.1.3.48
GO:0004725Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. GO:0006470The process of removing one or more phosphoric residues from a protein.
0.616 Hit 61.0% 2.24e-11
3919 PA2976 ribonuclease E rne, PA2976 Experimental + AlphaFold
3.1.26.12
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0000287Binding to a magnesium (Mg) ion. +1114 total
0.616 No Hit N/A —
3920 PA2957 transcriptional regulator PA2957 Experimental + AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.616 No Hit N/A —
3921 PA2603 thiosulfate sulfurtransferase PA2603 Experimental + AlphaFold –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+.
0.616 No Hit N/A —
3922 PA2212 4-hydroxythreonine-4-phosphate dehydrogenase PA2212 AlphaFold
1.1.1.262
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050570Catalysis of the reaction: 4-(phosphooxy)-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. GO:0046872Binding to a metal ion. +25 total
0.616 No Hit N/A —
3923 PA1264 transcriptional regulator PA1264 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.616 No Hit N/A —
3924 PA0208 malonate decarboxylase subunit alpha PA0208, mdcA Experimental + AlphaFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.616 No Hit N/A —
3925 PA4749 phosphoglucosamine mutase PA4749, glmM AlphaFold
5.4.2.10
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000287Binding to a magnesium (Mg) ion. GO:0004614Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. +710 total
0.615 Hit 25.9% 7.42e-08
Page of 223 · 5572 total proteins