Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3951 PA2095 hypothetical protein PA2095 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.612 No Hit N/A —
3952 PA1059 monovalent cation/H+ antiporter subunit G PA1059 AlphaFold –
GO:0015385Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). GO:0035725A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). +14 total
0.612 No Hit N/A —
3953 PA4080 response regulator PA4080 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.611 No Hit N/A —
3954 PA3607 polyamine transporter ATP-binding protein PotA potA ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.611 Hit 52.3% 6.14e-07
3955 PA0451a amino acid ABC transporter substrate-binding protein ColabFold – – 0.611 No Hit N/A —
3956 PA5398 dimethylglycine catabolism protein DgcA dgcA, PA5398 AlphaFold –
GO:0047865Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein. GO:0047866Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = formaldehyde + H2O2 + sarcosine. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +36 total
0.61 No Hit N/A —
3957 PA5363 hypothetical protein PA5363 AlphaFold –
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.61 No Hit N/A —
3958 PA4420 S-adenosyl-methyltransferase MraW mraW, PA4420, rsmH AlphaFold
2.1.1.199
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0071424Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. GO:0070475The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. +14 total
0.61 Hit 41.8% 4.83e-36
3959 PA3703 chemotaxis-specific methylesterase wspF ColabFold –
GO:0008984Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.61 No Hit N/A —
3960 PA3598 hypothetical protein PA3598 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
0.61 Hit 31.9% 3.35e-13
3961 PA3149 glycosyltransferase WbpH wbpH, PA3149 AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0009243The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.
0.61 No Hit N/A —
3962 PA2898 hypothetical protein PA2898 AlphaFold – – 0.61 No Hit N/A —
3963 PA2560 hypothetical protein PA2560 AlphaFold – – 0.61 No Hit N/A —
3964 PA2509 muconate cycloisomerase I catB, PA2509 AlphaFold –
GO:0018850Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0030145Binding to a manganese ion (Mn). +58 total
0.61 No Hit N/A —
3965 PA1386 ABC transporter ATP-binding protein PA1386 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.61 Hit 30.7% 2.12e-07
3966 PA0967 Holliday junction ATP-dependent DNA helicase RuvB ruvB, PA0967 Experimental + AlphaFold
3.6.4.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009379A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA. GO:0048476An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated. +1114 total
0.61 Hit 25.7% 3.07e-06
3967 PA0582 dihydroneopterin aldolase folB, PA0582 AlphaFold
4.1.2.25
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004150Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. +36 total
0.61 No Hit N/A —
3968 PA0395 twitching motility protein PilT PA0395, pilT Experimental + AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0044096A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.61 No Hit N/A —
3969 PA0163 transcriptional regulator PA0163 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.61 No Hit N/A —
3970 PA0004 DNA gyrase subunit B PA0004, gyrB Experimental + AlphaFold
5.6.2.2
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
0.61 Hit 24.0% 2.97e-31
3971 PA3997 lipoate-protein ligase B PA3997, lipB AlphaFold
2.3.1.181
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033819Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]. GO:0009249The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. +14 total
0.609 Hit 43.2% 7.13e-12
3972 PA3179 ribosomal large subunit pseudouridine synthase B PA3179, rluB AlphaFold
5.4.99.22
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0160139Catalysis of the reaction: uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA. GO:0003723Binding to an RNA molecule or a portion thereof. +58 total
0.609 No Hit N/A —
3973 PA2545 exonuclease III PA2545, xthA AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0008311Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. +69 total
0.609 Hit 36.0% 4.52e-09
3974 PA2236 biofilm formation protein PslF pslF, PA2236 AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
0.609 No Hit N/A —
3975 PA1506 hypothetical protein PA1506 AlphaFold – – 0.609 No Hit N/A —
Page of 223 · 5572 total proteins