Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4051 PA1818 lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA ldcA, PA1818 AlphaFold
4.1.1.18
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008923Catalysis of the reaction: L-lysine + H+ = cadaverine + CO2. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. +25 total
0.6 No Hit N/A —
4052 PA1062 hypothetical protein PA1062 AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.6 No Hit N/A —
4053 PA0698 hypothetical protein PA0698 AlphaFold – – 0.6 No Hit N/A —
4054 PA5541 dihydroorotase pyrQ, PA5541 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004038Catalysis of the reaction: allantoin + H2O = allantoate. GO:0004151Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+. +69 total
0.599 Hit 36.5% 4.54e-06
4055 PA3012 hypothetical protein PA3012 AlphaFold – – 0.599 No Hit N/A —
4056 PA1240 enoyl-CoA hydratase PA1240 Experimental + AlphaFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008203The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. GO:0006635A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
0.599 Hit 30.5% 3.63e-12
4057 PA1200 hypothetical protein PA1200 AlphaFold –
GO:0008171Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. GO:0008757Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.599 Hit 46.2% 1.00e-38
4058 PA0301 spermidine ABC transporter substrate-binding protein SpuE PA0301, spuE Experimental + AlphaFold –
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0019810Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. +58 total
0.599 No Hit N/A —
4059 PA5036 glutamate synthase subunit alpha PA5036, gltB AlphaFold
1.4.1.13
GO:0051538Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing. GO:0004355Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH4+ = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH4+ + 2-oxoglutarate + NADPH + H+. GO:0015930Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. +69 total
0.598 No Hit N/A —
4060 PA3692 outer membrane porin F PA3692, lptF AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.598 No Hit N/A —
4061 PA3162 30S ribosomal protein S1 PA3162, rpsA AlphaFold –
GO:0022627The small subunit of a ribosome located in the cytosol. GO:0003729Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +47 total
0.598 Hit 44.4% 4.83e-07
4062 PA2854 hypothetical protein PA2854 AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0071972Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +36 total
0.598 No Hit N/A —
4063 PA4083 chaperone CupB4 cupB4, PA4083 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0044183Binding to a protein or a protein-containing complex to assist the protein folding process. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +25 total
0.597 No Hit N/A —
4064 PA3309 hypothetical protein PA3309 AlphaFold – – 0.597 No Hit N/A —
4065 PA2360 hypothetical protein PA2360 AlphaFold – – 0.597 No Hit N/A —
4066 PA1169 arachidonate 15-lipoxygenase PA1169, loxA Experimental + AlphaFold
1.13.11.- 1.13.11.33
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0050473Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. +58 total
0.597 Hit 33.4% 1.30e-40
4067 PA0498 hypothetical protein PA0498 AlphaFold –
GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
0.597 No Hit N/A —
4068 PA5472 hypothetical protein PA5472 AlphaFold – – 0.596 No Hit N/A —
4069 PA5172 ornithine carbamoyltransferase arcB, PA5172 Experimental + AlphaFold
2.1.3.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0004585Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. +69 total
0.596 Hit 38.9% 3.54e-06
4070 PA5141 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase PA5141, hisA AlphaFold
5.3.1.16
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003949Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
0.596 No Hit N/A —
4071 PA3733a hypothetical protein ColabFold – – 0.596 No Hit N/A —
4072 PA2259 transcriptional regulator PtxS ptxS, PA2259, kdgR_3 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +47 total
0.596 No Hit N/A —
4073 PA2171 hypothetical protein PA2171 AlphaFold – – 0.596 No Hit N/A —
4074 PA1415 hypothetical protein PA1415, halS AlphaFold –
GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
0.596 Hit 39.7% 6.64e-45
4075 PA1356 hypothetical protein PA1356 AlphaFold –
GO:0010411The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants. GO:0005515Binding to a protein.
0.596 No Hit N/A —
Page of 223 · 5572 total proteins