Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4076 PA0382 tRNA (guanine-N(7)-)-methyltransferase micA ColabFold –
GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. GO:0008176Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine.
0.596 Hit 26.3% 3.51e-07
4077 PA0378 monofunctional biosynthetic peptidoglycan transglycosylase PA0378, mtgA AlphaFold
2.4.99.28
GO:0009274A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). +58 total
0.596 No Hit N/A —
4078 PA0328 hypothetical protein PA0328 AlphaFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. GO:0015474Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively. +47 total
0.596 No Hit N/A —
4079 PA0289 transcriptional activator GpuR PA0289, gpuR AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.596 No Hit N/A —
4080 PA5050 primosome assembly protein PriA PA5050, priA AlphaFold
5.6.2.4
GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. GO:0043138Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +1114 total
0.595 No Hit N/A —
4081 PA4624 hypothetical protein PA4624 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0098046A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). GO:0008320Enables the transfer of a protein from one side of a membrane to the other. +25 total
0.595 No Hit N/A —
4082 PA4281 exonuclease SbcD PA4281, sbcD AlphaFold –
GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0004529Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. +69 total
0.595 No Hit N/A —
4083 PA3858 amino acid-binding protein PA3858 AlphaFold –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.595 No Hit N/A —
4084 PA3725 single-stranded-DNA-specific exonuclease RecJ recJ, PA3725 AlphaFold –
GO:0003676Binding to a nucleic acid. GO:0045145Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +25 total
0.595 No Hit N/A —
4085 PA3397 ferredoxin-NADP reductase fpr, PA3397 Experimental + AlphaFold
1.18.1.2
GO:0004324Catalysis of the reaction: 2 reduced [2Fe-2S]-[ferredoxin] + NADP+ + H+ = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0034599Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. +25 total
0.595 No Hit N/A —
4086 PA3048 ribosomal RNA large subunit methyltransferase K/L rlmL, PA3048 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0052915Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine. GO:0003723Binding to an RNA molecule or a portion thereof. +69 total
0.595 No Hit N/A —
4087 PA3025 FAD-dependent glycerol-3-phosphate dehydrogenase PA3025 AlphaFold –
GO:0004368Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0046168The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. +36 total
0.595 Hit 31.6% 1.27e-40
4088 PA1684 acireductone dioxygenase mtnD, PA1684 AlphaFold
1.13.11.54 1.13.11.53
GO:0010308Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + CO + formate. GO:0010309Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+. GO:0005506Binding to an iron (Fe) ion. +47 total
0.595 Hit 35.1% 2.29e-08
4089 PA1091 flagellar glycosyl transferase FgtA fgtA, PA1091 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0047355Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP. GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. +14 total
0.595 No Hit N/A —
4090 PA3905 hypothetical protein PA3905 AlphaFold – – 0.594 No Hit N/A —
4091 PA3405 metalloprotease secretion protein hasE, PA3405 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.594 No Hit N/A —
4092 PA2767 enoyl-CoA hydratase PA2767 AlphaFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006635A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
0.594 Hit 44.6% 9.31e-06
4093 PA2193 hydrogen cyanide synthase subunit HcnA hcnA, PA2193 AlphaFold
1.4.99.5
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0050622Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2. +25 total
0.594 No Hit N/A —
4094 PA1515 allantoicase alc, PA1515 AlphaFold
3.5.3.4
GO:0004037Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea. GO:0000256The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. GO:0006144The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
0.594 Hit 36.4% 2.54e-78
4095 PA5257 hypothetical protein PA5257 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042168The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0006779The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. +25 total
0.593 No Hit N/A —
4096 PA3782 transcriptional regulator PA3782 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.593 No Hit N/A —
4097 PA2785 hypothetical protein PA2785 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.593 No Hit N/A —
4098 PA1151 pyocin-S2 immunity protein PA1151, imm2 Experimental + AlphaFold –
GO:0015643Binding to a toxic substance, a poisonous substance that causes damage to biological systems. GO:0030153A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.
0.593 No Hit N/A —
4099 PA1150 pyocin-S2 PA1150, pys2 Experimental + AlphaFold
3.1.-.-
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. +58 total
0.593 No Hit N/A —
4100 PA0995 methylated-DNA--protein-cysteine methyltransferase PA0995, ogt AlphaFold
2.1.1.63
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003908Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. GO:0006307The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases. +36 total
0.593 Hit 39.5% 2.34e-19
Page of 223 · 5572 total proteins