Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4476 PA4978 hypothetical protein PA4978 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. GO:0061733Catalysis of the reaction: L-lysyl-[protein] + acetyl-CoA = N6-acetyl-L-lysyl-[protein] + CoA + H+.
0.522 No Hit N/A —
4477 PA4458 hypothetical protein PA4458 AlphaFold
3.1.3.45
GO:0019143Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. GO:0046872Binding to a metal ion. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. +14 total
0.522 Hit 34.2% 2.72e-20
4478 PA3689 transcriptional regulator PA3689 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0046872Binding to a metal ion. +25 total
0.522 No Hit N/A —
4479 PA2706 hypothetical protein PA2706 AlphaFold –
GO:0016846Catalysis of the elimination of hydrogen sulfide or substituted H2S. GO:0046872Binding to a metal ion.
0.522 No Hit N/A —
4480 PA1868 secretion protein XqhA PA1868, xqhA AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. +36 total
0.522 No Hit N/A —
4481 PA1793 peptidyl-prolyl cis-trans isomerase B PA1793, ppiB AlphaFold
5.2.1.8
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +14 total
0.522 Hit 38.5% 3.14e-07
4482 PA1475 cytochrome c biogenesis ATP-binding export protein CcmA PA1475, ccmA AlphaFold
7.6.2.5
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015439Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.522 Hit 34.7% 3.02e-14
4483 PA0926 hypothetical protein PA0926 AlphaFold – – 0.522 No Hit N/A —
4484 PA0618 bacteriophage protein JR2, PA0618 Experimental + AlphaFold – – 0.522 No Hit N/A —
4485 PA4977 hypothetical protein PA4977, aruI AlphaFold
4.1.1.75
GO:0005948A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate. GO:0047435Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2. GO:0003984Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. +710 total
0.521 Hit 40.2% 2.46e-10
4486 PA2970 50S ribosomal protein L32 PA2970, rpmF AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.521 No Hit N/A —
4487 PA1437 two-component response regulator PA1437 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +47 total
0.521 No Hit N/A —
4488 PA0599 hypothetical protein PA0599 AlphaFold – – 0.521 No Hit N/A —
4489 PA5180 hypothetical protein PA5180, fdhD AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). +25 total
0.52 No Hit N/A —
4490 PA4710 heme/hemoglobin uptake outer membrane receptor PhuR PA4710, phuR AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0015232Enables the transfer of heme from one side of a membrane to the other. +69 total
0.52 No Hit N/A —
4491 PA2709 cysteine synthase A PA2709, cysK AlphaFold
2.5.1.47
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004124Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. GO:0080146Catalysis of the reaction: L-cysteine + H2O = hydrogen sulfide + pyruvate + NH4+ + H+. +14 total
0.52 Hit 52.4% 8.11e-25
4492 PA2282 hypothetical protein PA2282 AlphaFold – – 0.52 No Hit N/A —
4493 PA1871 protease LasA lasA, PA1871 Experimental + AlphaFold
3.4.24.-
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0004175Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. GO:0046872Binding to a metal ion. +58 total
0.52 No Hit N/A —
4494 PA1382 type II secretion system protein PA1382 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0009306The controlled release of proteins from a cell.
0.52 No Hit N/A —
4495 PA1331 hypothetical protein PA1331 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.52 No Hit N/A —
4496 PA1242 hypothetical protein PA1242 AlphaFold –
GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0071978Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. +69 total
0.52 No Hit N/A —
4497 PA5269 hypothetical protein PA5269 AlphaFold – – 0.519 No Hit N/A —
4498 PA1255 trans-3-hydroxy-L-proline dehydratase PA1255, lhpL AlphaFold
5.1.1.- 4.2.1.77
GO:0047580Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline. GO:0050346Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+.
0.519 Hit 30.2% 1.94e-11
4499 PA0481 hypothetical protein PA0481 AlphaFold – – 0.519 No Hit N/A —
4500 PA4709 hemin degrading factor PA4709 AlphaFold –
GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.518 No Hit N/A —
Page of 223 · 5572 total proteins