Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4501 PA2105 acetyltransferase PA2105 AlphaFold
2.3.1.30
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009001Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. GO:0019344The chemical reactions and pathways resulting in the formation of L-cysteine, 2-amino-3-mercaptopropanoic acid. +25 total
0.518 No Hit N/A —
4502 PA0418 hypothetical protein PA0418 AlphaFold – – 0.518 No Hit N/A —
4503 PA5323 acetylglutamate kinase argB, PA5323 Experimental + AlphaFold
2.7.2.8
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003991Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.517 No Hit N/A —
4504 PA3000 aromatic amino acid transporter AroP PA3000, aroP1 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.517 Hit 25.1% 1.62e-13
4505 PA1222 membrane-bound lytic murein transglycosylase A PA1222 AlphaFold
4.2.2.n1
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. +36 total
0.517 No Hit N/A —
4506 PA4555 type 4 fimbrial biogenesis protein PilY2 PA4555, pilY2 Experimental + AlphaFold –
GO:0043107Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.
0.516 No Hit N/A —
4507 PA3545 alginate-c5-mannuronan-epimerase AlgG PA3545, algG AlphaFold
5.1.3.37
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0042121The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).
0.516 No Hit N/A —
4508 PA1828 short-chain dehydrogenase PA1828 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.516 Hit 40.3% 1.86e-09
4509 PA1042 hypothetical protein PA1042 AlphaFold – – 0.516 No Hit N/A —
4510 PA0404 Holliday junction resolvase PA0404 AlphaFold
3.1.-.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0004518Catalysis of the cleavage of ester linkages within nucleic acids. +36 total
0.516 No Hit N/A —
4511 PA0136 ABC transporter ATP-binding protein PA0136 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
0.516 Hit 32.9% 8.32e-17
4512 PA5495 homoserine kinase PA5495, thrB AlphaFold
2.7.1.39
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004413Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+. GO:0009088The chemical reactions and pathways resulting in the formation of L-threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
0.515 No Hit N/A —
4513 PA5303 hypothetical protein PA5303 AlphaFold – – 0.515 Hit 30.6% 2.10e-11
4514 PA1726 beta-glucosidase PA1726, bglX Experimental + AlphaFold
3.2.1.21
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0008422Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. GO:0046872Binding to a metal ion. +36 total
0.515 No Hit N/A —
4515 PA0346 hypothetical protein PA0346 AlphaFold – – 0.515 No Hit N/A —
4516 PA0037 HTH-type transcriptional regulator TrpI PA0037, trpI AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +47 total
0.515 No Hit N/A —
4517 PA4025 ethanolamine ammonia-lyase small subunit PA4025, eutC AlphaFold
4.3.1.7
GO:0009350An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. GO:0031471An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase. GO:0031419Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +36 total
0.513 No Hit N/A —
4518 PA2826 glutathione peroxidase PA2826 AlphaFold –
GO:0004601Catalysis of the reaction: a reduced substrate + ROOH = an oxidized substrate + ROH + H2O. GO:0034599Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. +14 total
0.513 Hit 56.5% 1.66e-16
4519 PA0952 hypothetical protein PA0952 AlphaFold – – 0.513 No Hit N/A —
4520 PA5500 zinc transporter ZnuC znuC, PA5500 AlphaFold
7.2.2.20
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0015633Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.512 Hit 31.2% 7.22e-14
4521 PA3411 hypothetical protein PA3411 AlphaFold – – 0.512 No Hit N/A —
4522 PA3136 secretion protein PA3136 AlphaFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.512 No Hit N/A —
4523 PA5499 transcriptional regulator PA5499, np20 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +811 total
0.511 No Hit N/A —
4524 PA3393 copper-binding periplasmic protein PA3393, nosD AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.511 No Hit N/A —
4525 PA3196 hypothetical protein PA3196 AlphaFold – – 0.511 No Hit N/A —
Page of 223 · 5572 total proteins